S. (2001b) RPA governs endonuclease switching during processing of Oka- zaki fragments in eukaryotes. Nature 412, 456-461.Bae SH,Bae KH,Kim JA,Seo YS.RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. Nature . 2001...
Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes - Kang, Lee, et al. - 2010 () Citation Context ... which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.2090 Nucleic Acids ...
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes Extensive work on the maturation of lagging strands during the replication of simian virus 40 DNA suggests that the initiator RNA primers of Okazaki fragm... SH Bae,KH Bae,JA Kim,... - 《Nature》 被引量:...
An Okazaki fragment is a relatively short fragment ofDNA(with no RNA primer at the 5' terminus) created on the lagging strand duringDNA replication. The lengths of Okazaki fragments are between 1,000 to 2,000 nucleotides long in E. coli and are generally between 100 to 200 nucleotides long...
In eukaryotes, the endonucleolytic activity of the calf RTH-1 class 5′- to 3′-exo/endonuclease can function without RNase H1 to remove initiator RNA from Okazaki fragments. Cleavage requires that the RNA be displaced to form an unannealed single-stranded 5′-tail or flap structure. On ...
responsibleformaturationofthe laggingstrand.Inbothprokaryotesandeukaryotesthelagging-strandfragmentsareinitiated byRNAprimers,whichareremovedbyajoiningmechanisminvolvingstranddisplacement oftheprimerintoaflap,flapremoval,andthenligation.Althoughtheprokaryoticfragments are1200nucleotideslong,theeukaryoticfragmentsaremuch...
A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes DNA ligase I joins Okazaki fragments during DNA replication and completes certain excision repair pathways. The participation of DNA ligase I in these tran... W Song,DS Levi...
These are short (generally less than 1 kilobase in eukaryotes and about 2 kb in prokaryotes) DNA sequences formed during replication (of the lagging strand) and subsequently ligated into a continuous...Springer NetherlandsEncyclopedia of Genetics Genomics Proteomics & Informatics...
Recent findings suggest that, in eukaryotes, the processing of Okazaki fragments occurs by a two-step mechanism governed by the single-stranded DNA binding factor RPA.Stuart A MacNeillCurrent BiologyMacNeill, S. A.: DNA replication: partners in the Okazaki two-step. Curr Biol, 11, R842-4 ...
Discusses the modulation of the strand displacement activity of DNA polymerase gamma by the concerted action of replication protein A, proliferating cell nuclear antigen and flap endonuclease. Major polymerase involved in chromosomal replication in eukaryotes; Model for Okazaki fragment processing; ...