Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Mechanism of action Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription....
• Hypersensitivity to any quinolone antibiotic Warnings & precautions • Tenotoxicity - tendinopathy, tendon rupture. Higher doses and longer duration of fluoroqinolone treatment increase the risk of tendon damage • Prolongation of the QT interval • Peripheral neuropathy • Central nervous sys...
Ofloxacin Otic Solution 0.3% is an antibiotic in a sterile solution used to treat ear infections caused by certain bacteria found in: patients (12 years and older) who have a middle ear infection and have a hole in the eardrum pediatric patients (between 1 and 12 years of age) who have ...
O H3C O H3C H3C OH H3C O CH3 HO O H3C N CH3 O CH3 OO CH3 OCH3 O OH CH3 (oleandomycin) Profile Oleandomycin is a macrolide antibacterial produced by the growth of certain strains of Streptomyces antibioticus with ac- tions and uses similar to those of erythromycin (p.269). It has ...
Ofloxacin is a fluoroquinolone antibiotic with anti-leprosy activity. Ofloxacin has a long half-life and is given as a single daily dose. Side-effects include nausea, diarrhoea and other gastrointestinal complaints, and skin rash may occur. A variety of central nervous system complaints have been ...
Ofloxacin is a synthetic broad-spectrum fluroquinolone antibiotic, frequently used for the treatment of ocular infections. In the present study, ionic gelation technique was employed as the method of preparation of ofloxacin loaded chitosan nanoparticles using different concentrations of chitosan and sodium...
Balofloxacin (Q-35) is an orally active fluoroquinolone antibiotic with broad-spectrum antibacterial activity against gram-negative, gram-positive, and anaerobic bacteria. Balofloxacin can be used for the research of respiratory, intestinal, and urinary tract infections. 体外研究 Balofloxacin (25 mg...
Nanoparticles encapsulating an antibiotic drug, ofloxacin, were fabricated using emulsion solvent evaporation technique adopting 23 full factorial design to evaluate the effect of formulation parameters: that is to say, the molecular weight of the polymer (polycaprolactone), amount of Kolliphor P188, and...
Micelle can offer to deliver vitamins, growth factors, and the antibiotic drug ofloxacin, one of the most widely used fluoroquinolones antibacterial agents, highly active against Gram-positive and Gram-negative bacteria. It is also active against mycoplasma, chlamydia, and legionella. The mechanism of...
Ofloxacin is a fluoroquinolone broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria for the treatment of infections. Ofloxacin is being used as eye drops in the treatment of eye infections. Rapid elimination and poor bioavailability is the disadvantage ...