The nuclear localization signal of periaxin (amino acids 118–196) comprises 3 highly basic sub-domains. The p.R167C mutation is located in the second sub-domain (amino acid sequence KFSRLRRGLKAEAVK). Full size image Ldb3p.R473W mutation in all of SAMP strains except for SAMP8 In the ...
More recently, Wang et al. performed a meta-analysis based on 22 studies including a total of 2013 RCC patients identified from various databases including PubMed [140]. The results showed that p53 positive expression is associated with poor overall survival (OS) (HR = 2.17, 95% confiden...
Cell classes in human retina To generate a comprehensive cell atlas of human retina, we obtained eight retinas from seven genetically unrelated human donors with no clinical history of ocular disease (TableS1). We dissected foveal (~1.5 mm diameter centered on the foveal pit, which was visible...
On the occasion of the 75th anniversary of the first volume of “Progress in the Chemistry of Organic Natural Products” and in addition, the publication of Volume 100, a retrospective examination is taken from its beginnings and through the remarkable development of this book series. The starting...
genome maintenance. One such nuclease is DNA2, which processes reversed fork ends following replication stalling in a WRN helicase-dependent manner and creates partially resected reversed fork intermediates amenable to restart by branch migration or HR mechanisms70. MRE11, CtIP, and EXO1 nucleases ...
Stimulus-secretion coupling (SSC) of pancreatic islet cells comprises electrical activity. Changes of the membrane potential (Vm) are regulated by metabolism-dependent alterations in ion channel activity. This coupling is best explored in β cells. The e
DNA-PK can inhibit HR activity, thereby favoring NHEJ [81]. Given its role in multiple DDR nodes, DNA-PKcs has become an attractive anti-cancer therapeutic target, especially in combination with genotoxic chemotherapy or radiation therapy. Many small molecule inhibitors of DNA-PKcs are currently...
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Owing to the high carbonate content of the Pleistocene beach rock, this sample was processed with 2N HCl for 24 hr to fully disaggregate the sample prior to hydrogen peroxide treatment. Processed subsamples were used for laser particle size analysis (LPSA) and whole rock, trace element, rare...
Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approaches for AD therapeutics th