Competitive polymerase chain reaction assays have been developed for the quantitation of oestrogen receptor mRNA and two oestrogen-regulated mRNAs (progesterone receptor and pNR-2/pS2) in breast cancer cells. These assays are more sensitive than traditional hybridisation techniques, do not require the ...
Although it has been shown that the combination of lapatinib and an aromatase inhibitor is not beneficial for ERBB2-negative, endocrine sensitive or endocrine naive metastatic breast cancer patients (Johnston et al, 2009), this remains to be established for BCAR4-positive tumours. We have shown ...
In patients with hormone-sensitive breast cancer tumour growth is mainly driven by oestrogen and patients are therefore treated with oestrogen-suppressing drugs, often tamoxifen. From Science Daily Levels of the hormone oestrogen fall sharply, increasing the risk of osteoporosis. From Science Daily This...
The development of breast cancer is strongly influenced by endogenous oestrogens (and other growth factors), leading to a strong focus on the development of antioestrogenic compounds for the treatment of hormone-sensitive advanced disease. This is a review of current endocrine therapies available for ...
The development of breast cancer is strongly influenced by endogenous oestrogens (and other growth factors), leading to a strong focus on the development of antioestrogenic compounds for the treatment of hormone-sensitive advanced disease. Design:This is a review of current endocrine therapies ...
Gene expression profiling classifies ER positive breast cancer into two main subtypes.1Luminal A tumours have a better prognosis than luminal B tumours, are tamoxifen sensitive and derive less benefit from adjuvant chemotherapy. A high Ki67 proliferation index (>14%) has been proposed as a cost-...
Define antioestrogen. antioestrogen synonyms, antioestrogen pronunciation, antioestrogen translation, English dictionary definition of antioestrogen. n a drug that inhibits the activity of oestrogens Collins English Dictionary – Complete and Unabridged,
Experimental approach: We examined the effect of the novel, clinically-trialed, thiosemicarbazone anti-cancer agent, DpC, and its potential as a combination therapy with the clinically used estrogen receptor (ER) antagonist, tamoxifen, using both tamoxifen-resistant and -sensitive cells. Key ...
Article: Immunohistochemical analysis of breast cancer oestrogen receptor status and its correlation with oestrogen receptor biochemical assay
Several anti-proliferative gene candidates were identified and their promoters were confirmed as more heavily methylated in the tamoxifen resistant vs sensitive cells. One such gene candidate, growth differentiation factor 15 (GDF15), was carried forward for functional analysis. The addition of 5-Aza/...