(Biochemistry) any of several steroid hormones, that are secreted chiefly by the ovaries and placenta, that induce oestrus, stimulate changes in the female reproductive organs during the oestrous cycle, and promote development of female secondary sexual characteristics ...
Background: A key event in Alzheimer’s disease pathology is the proteolytic processing of amyloid precursor protein (APP), whereby β-amyloid (Aβ) peptide is produced. Oestrogen is acknowledged to influence cognitive function and has been shown to regulate the secretory...
Zearalenone is produced byFusarium graminearumand several otherFusariumspecies, all of which are found in abundance in association with grains. As such, this has been described as the most common of the mycotoxins associated withFusariumand it has been stated that up to approximately one-quarter of...
Zearalenone (ZEN) is the nonsteroidal mycoestrogen produced by Fusarium fungi and has been detected in cereal grains, animal feed, and ruminant urine worldwide. Zearalenone has a prolonged blood half-life that results from enterohepatic cycling. There are five metabolites of ZEN: α-zearalanol (...
摘要: It is now widely accepted that biological effects produced by oestrogens in target tissues occur as a result of hormone binding to a specific protein receptor. Receptors for oestrogen have been identified in steroid target tissues such as lactating mammary gland...
Lentivirus was produced by calcium phosphate transfection of 293T cells [16]. To transduce HMECs with multiple genes, infections were performed simultaneously with different viruses: cells were infected in suspension with the ERα and BMI1 vectors 24 hours after harvest from the patient (that is,...
This is called the 'expression signature' of the compound. Similarities or differ- ences between gene expression profiles produced by compounds R and Q can be calculated using Euclidian distance D [R,Q]: ÃD½R; Q ¼ ½ð1=nÞÆiðRi QiÞ21=2 ð2Þ where n...
What hormone is produced by the Theca and Granulosa cells of the tertiary follicle? A. Progesterone B. GnRH C. LH D. Testoterone E. Estrogen F. FSH What hormone is produced by the placental tissue and stimulates the corpus luteum to continue i...
This may be also caused by an oestrogen-induced PR expression, because PR gene is well known to have oestrogen-response element and to be controlled by oestrogen (Thi et al, 1975; Nardulli et al, 1988; Wei et al, 1988). Oestrone sulphate cannot bind to ER at all and therefore fails ...
This scattered or diffuse cell loss response is also observed after neoadjuvant chemotherapy in ER+ tumours [29]. While pathological assessment considers the maximum area occupied by the tumour and does not capture this scattered response, radiological evaluation after NET may reflect the diffuse ...