Also estrogen receptors may not be the only factor involved. The receptor status of the primary tumor and of the metastases was considered the same. Cases were reported of carcinomas with both types of receptor response in different areas. It was thought that the treatment may change the ratio...
Importantly, the stage and grade of endometrial cancers observed in women taking tamoxifen are the same as the general population [42]. 3. Drug resistance to tamoxifen Although tamoxifen is classified as an anti-oestrogen for the use as a breast cancer treatment, the action of the drug is ...
The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. CONCLUSIONS: ORalpha polymorphisms are significantly associated with the age at disease onset in Koreans with SLE. 展开 关键词: Humans Receptors, Estrogen Estrogen Receptor alpha Gene ...
Differences between oestrogen receptor activation by oestrogen and antiestrogen. ?Vutiire292:257-259.Rochefort H. and Borgna J. L.: Differences between oestrogen receptor activation by oestrogen and anti- oestrogen: Nature 292 (1981) 257-259....
as they respond to hormonal manipulation. SeeTamoxifen. ERs are transcription factors that are regulated allosterically by binding a ligand; extracellular estradiol diffuses across the cell membrane, binds to the ER, leading to its dimerization and binding of ER to the estrogen responsive element, th...
Bunone G, Briand PA, Miksicek RJ, Picard D (1996) Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. Embo J 15:2174–2183 PubMed CAS Google Scholar Burleigh I (1980) Growth curves in muscle nucleic acid and protein: problems ...
Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer Article Open access 29 November 2022 An emerging generation of endocrine therapies in breast cancer: a clinical perspective Article Open access...
64Cu-SAR-Bombesin PET-CT Imaging in the Staging of Estrogen/Progesterone Receptor Positive, HER2 Negative Metastatic Breast Cancer Patients: Safety, Dosime... 3092#Background:Breast cancers are most frequently oestrogen receptor (ER) and progesterone receptor (PR) positive and18F-Fluorodeoxyglucose PET...
REFERENCES Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, Kudo N, Koguchi M, Niikawa H, Suzuki S, Evans DB, Sugawara S, Suzuki T, Sasano H (2010) Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer. Hum Pathol 41: 190–198....
Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins ObjectiveThe purpose of this study was to evaluate the effects of the contraceptive patch and an oral contraceptive (OC) on serum concentrations of estroge... T White,B ?Zel,JK Jain,... - 《Contraception》 被...