This updated version of the original guideline 406, adopted in 1981, is the outcome of a meeting of OECD experts held in Paris in May 1991. 2. Currently, quantitative structure-activity relationships and in vitro models are not yet sufficiently developed to play a significant role in the ...
TestGuideline404(TG404);adoptedin1981andrevisedin1992and2002)(2).Inrelationtoanimal15 welfareTG404wasrevisedin2002,allowingforthedeterminationofskincorrosionbyapplyingatiered16 testingstrategy,usingvalidatedinvitroorexvivotestmethods,thusavoidingpainandsufferingof17 ...