Skin Irritation (OECD TG 439) Skin irritation refers to the production of reversible damage to the skin following the application of a test substance. Understanding the potential of topically-applied chemicals or formulations to induce skin irritation (hazard) is an important consideration in their ...
2. The assessment of skin irritation has typically involved the use of laboratory animals [OECD TG 404; adopted in 1981 and revised in 1992 and 2002](4). In relation to animal welfare concerns, TG 404 was revised in 2002, allowing for the determination of skin corrosion/irritation by ...
8. This Test Guideline addresses the in vitro skin irritation component of the tiered testing strategy of TG 404 on dermal corrosion/irritation (4). While this Test Guideline does not provide adequate information on skin corrosion, it should be noted that OECD TG 431 on skin corrosion is ...
OECD TG 439ReproducibilityPredictive capacitySkin irritationWe conducted a me-too validation study to confirm the reproducibility, reliability, and predictive capacity of KeraSkin (TM) skin irritation test (SIT) as a me-too method of OECD TG 439. With 20 reference chemicals, within-laboratory ...
急性吸入毒性OECD TG426急性毒性分类法 皮肤刺激/腐蚀性OECD 430人工皮肤模型腐蚀实验 OECD 431大鼠经皮肤电阻实验 OECD 439皮肤刺激的重组人表皮模型试验 OECD 435皮肤腐蚀的体外膜屏障试验方法 眼刺激性/腐蚀性OECD 437牛角膜混浊和渗透性试验(BCOP) OECD 438离体鸡眼试验 ...
2. The assessment of skin irritation has typically involved the use of laboratory animals [OECD TG 404; originally adopted in 1981 and revised in 1992, 2002 and 2015] (4). For the testing of corrosivity, three validated in vitro test methods have been adopted as OECD TGs 430, 431 and ...
This test is described in TG439, In vitro Skin Irritation: Reconstructed human Epidermis (RhE) Test Method. EPI-MODEL24 SCT (Skin Corrosion Test) was also validated and approved in TG431, In vitro Skin Corrosion: Reconstructed human Epidermis (RhE) Test Method. Numerous test developers have ...
439 OECD/OCDE 2 © OECD, (2015) (28) based on the RhE test system (sensitivity 80%, specificity 70%, and accuracy 75%). These four test methods are included in this TG and are listed in Annex 2, which also provides information on the type of ...
TG Gregory Lemkine OECD TG 439-Skin irritation validation studiespresentation includes several case studiesHelena Kandarova OECD TG 442E on skin sensitisationValidation of GARDSkin Henrik Johansson EU-NETVAL validation studies-EURL ECVAM-AR CALUX validation studyOECD TG 458-Thyroid validation study18 ...
2013年7月26日,经济合作与发展组织(Organization for Economic Co-operation andDevelopment.OECD)再次更新试验指南TG431和TG439(以下简称2013版指南),对于体外皮肤腐蚀性、刺激性试验提出更详尽的要求。 大量的研究促使人类皮肤模型不断进步,从依靠滋养层培养到表皮替代物以及多种类型细胞共培养系统。目前皮肤模型主要分...