406 Adopted: 17.07.92 OECD GUIDELINE FOR TESTING OF CHEMICALS Adopted by the Council on 17 th July 1992 Skin Sensitisation INTRODUCTION 1. OECD Guidelines for Testing of Chemicals are periodically reviewed in light of scientific progress. In such reviews, special attention is given to...
Depending on regulatory requirements, the skin sensitization risk for new chemicals with potential consumer skin contact must be assessed by experimental testing by (i) binary hazard assessment to identify sensitizers, (ii) subclassification of sensitizers according to the Global Harmonized System (GHS),...
pigtests(OECDTG406)fortheskinsensitizationtestbuttheuseofaradioisotopicagent, 3 H-thymidine, detersitsactivedissemination.Newnon-radioisotopicLLNA,LLNA:BrdU-FCMemploysanon- radioisotopicanalog,5-bromo-2 0 -deoxyuridine(BrdU)andflowcytometry.Forananalogousmethod, OECDTG429performancestandard(PS)advisesthat...
skin sensitizationin vitro testingpoint of departurepotencyrisk assessmenthuman dataanimal dataSkin sensitizer potency assessment based on New Approach Methodologies (NAM) is key to derive a Point of Departure (PoD) for risk assessment. Regression models to predict a PoD based on OECD vali...
Skin sensitizationOECD TG442BLLNA-BrdUELISAGHSSub-categorizationThe Globally Harmonized System of Classification and Labelling of Chemicals (GHS) is a hazard classification and communication system for providing information on the safe handling of chemicals worldwide. While the GHS provides sub-...