In this chapter, we will discuss the role of two transcription factors, Oct4 (POU5F1) and Oct1 (POU2F1), in cancer stem cell identity and function. Oct4 is a key regulator of pluripotency in embryonic stem cells and is an obvious candidate regulator of cancer stem cells. Nevertheless, ...
[16] Liu C, Lu Y, Wang B,et al. Clinical implications ofstem cellgene Oct-4 expression in breast cancer [J]. Annals of surgery, 2011, 253(6): 1165-1171. [17]Miyazawa K, Tanaka T, Nakai D,et al. Immunohistochemical expression of four different stem cell markers in prostate cancer:...
ectopic Oct4 expression has been shown to enhance the features of cancer stem cells in a mouse model of breast cancer [51]. Oct4 expression has also been shown to maintain CSC-like properties in CD133-derived lung cancer cells [52]. Overall, these studies highlight the ...
oct-4 expression in aduit human stem cells: evidence in support of the stem cell theory of carcinogenesis j carcinogenesis, 2005, 26: 495-502_15 trosko je. from adult stem cells to cancer stem cells: oct-4 gene, cell-cell communication,and hormones during tumor promotion j ann n y 16...
Single cell suspension of prostatic cancer was prepared.Untreated stem cells and those resisting to hormone therapy were selected according to the marker of cells surface with flow cytometry;the Oct-4 gene and protein expression in hormone independent prostatic cancer was examined by RT-PCR and ...
The expression of OCT4 has further been shown in human breast cancer stem-like cells, implicating its involvement in tumorigenesis and self-renewal by activating its downstream target genes, such as NANOG and SOX213. NANOG, a downstream target of OCT4, contributes to cell fate determination of ...
肿瘤在疾病死亡率及死亡原因构成中占第一位.肿瘤的发生是多因素,多阶段,多基因相互作用的结果,其治疗后发生的复发转移,药物耐受和放疗抵抗等导致迄今仍无法根治肿瘤.近年来,肿瘤的发生与胚胎发育间的相似性一直受到关注.随着干细胞研究的迅猛发展,肿瘤干细胞(Cancer stem cell)假说及相关研究逐渐成为热点.该假说认为,...
Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and performed ...
结论Oct-4异常表达可能与胰腺癌始发有关,胰腺癌可能来源于胰腺干细 胞. 【关键词】胰腺肿瘤;干细胞;Oct-4 Theexpressionofembryostemcells(Oct-4inpancreaticcancer.DUZhi—yong,WEICui— fengHU Jun,WANGMin,QINRen—yi.DepartmentofPancreatic— BiliarySurgery,TongjiHospital, TongjiMedicalCollege,HuazhongUniversity...
SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma [J]. Nature, 2014, 511(7508): 246. CUSABIO精品推介 OCT4 Monoclonal Antibody(CSB-MA018403A0m) 宿主: Mouse 种属反应性:Human, Mouse, Rat 应用范围:ELISA, WB, IHC, IF, FC...