However, this may be offset by the fact that when most of the cohort studies used were initiated, there were fewer intervention strategies to reduce risk factors associated with obesity and fewer medical therapies for postponing death from obesity-related diseases. An increase in the efficacy and ...
Nowadays, obesity is one of the largest public health problems worldwide. In the last few decades, there has been a marked increase in the obesity epidemic and its related comorbidities. Worldwide, more than 2.2 billion people (33%) are affected by overweight or obesity (712 million, 10%) ...
Ethical approval was not sought for this specific project because all data came from the summary statistics of published GWAS, and no individual-level data were used. Genetic instruments for obesity and related risk factors Genetic instruments were identified as a panel of single-nucleotide ...
Nevertheless, the possible mechanisms underlying this association are not yet clear, and several obesity-related diseases have been suggested, including hyperinsulinemia and insulin resistance, abnormalities in hormone biosynthesis and hormonal pathways, circadian rhythm disturbances, and alterations in the ...
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Obesity diminishes almost every aspect of health, from reproductive and respiratory function to memory and mood. Excess weight substantially increases the risk of morbidity from hypertension; dyslipidemia; type 2 diabetes; coronary heart disease; stroke;
L. Prevalence of Overweight, Obesity, and Severe Obesity Among Children and Adolescents Aged 2–19 Years: United States, 1963–1965 Through 2015–2016 (National Center for Health Statistics, 2018); https://www.cdc.gov/nchs/data/hestat/obesity_child_15_16/obesity_child_15_16.pdf Skinner, ...
MS Pepe,RC Whitaker,K Seidel - 《Statistics in Medicine》 被引量: 115发表: 1999年 Obesity and colorectal cancer:Role of adipokines in tumor initiation and progression Obesity-associated diseases account for a large portion of public health challenges.Among obesity-related disorders,a direct and ind...
3,4 Such increases will tremendously affect public health since obesity is strongly associated with several chronic diseases, such as cardiovascular diseases and diabetes.5,6 Recent estimates suggest that obesity-related morbidity may account for 6.8% of US health care costs.7 Recently published trend...
Funding/Support: This work was supported by the National Institutes of Health (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (grant R01DK102794 to principal investigator Dr Page). A Research Electronic Data Capture, REDCap, database was used for this study, which is sup...