O-linked beta--acetylglucosamine (O-GlcNAc) is a dynamic and ubiquitous posttranslational modification of serine and threonine residues on nuclear and cytoplasmic proteins. O-GlcNAc has emerged as an important regulator of cellular processes such as cell signaling, transcription, translation, apoptosis,...
Since its discovery in the early 1980s, O-linked-β- N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. While other forms of protein glycosylation modify proteins on the cell surface ...
Increased levels of protein O-linked N-acetylglucosamine (O-GlcNAc) have been shown to increase cell survival following stress. Therefore, the goal of this... V Champattanachai,RB Marchase,JC Chatham - 《Am J Physiol Cell Physiol》 被引量: 415发表: 2007年 Glucosamine protects neonatal cardiom...
Background:Since its discovery in the early 1980s, O-linked-beta-N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. While other forms of protein glycosylation modify proteins on the cel...
"Role of the O-linked beta-N-acetylglucosamine in the cardioprotection induced by isoflurane." Anesthesiology 115(5): 955-962.Hirose, K.; Tsutsumi, Y.M.; Tsutsumi, R.; Shono, M.; Katayama, E.; Kinoshita, M.; Tanaka, K.; ... Kayo Hirose,Yasuo M Tsutsumi,Rie Tsutsumi,... - 《An...
Our strategy comprises the introduction of simple O-linked β- N -acetylglucosamine (O-GlcNAc) groups at the Ser/Thr sites that effectively improve the folding of disulfide-rich proteins by stabilization of their folding intermediates. After folding, the O-GlcNAc groups can be efficiently removed ...