beta cell (B-cell) diabetes epigenetics insulin O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (PTM) RNASeq Introduction Type II diabetes-related complications continue to be a leading cause of death in the United States (1). In the diabetic condition, hyperglycemia results...
Background:Since its discovery in the early 1980s, O-linked-beta-N-acetylglucosamine (O-GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues, has changed our views of protein glycosylation. While other forms of protein glycosylation modify proteins on the cel...