An example of a CAZyme whose mechanism has been studied using QM/MM techniques as a starting point to design novel inhibitors is O-glycoprotein 2-acetamino-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase), a member of the GH84 family (Lombard et al., 2014). O-GlcNAcase hydrolyzes O-GlcNAc...
TheO-glycoprotein is typically found in mucins, which are characterized by their heavily glycosylated tandem repeat regions. As an example ofO-glycoprotein synthesis, the preparation of the repeating sequence of mucin by the ligation method is briefly descried. Fmoc-Ser/Thr units carrying glycan cha...
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, availabl
The appearance of a branch Galβ1-3(GlcNAcβ1-6)GalNAc in O -glycans has been demonstrated in many important biological processes such as T cell activation, T cell development, leukemia, immunodeficiencies (Tsuboi and Fukuda 2001), and cancer metastasis (Tsuboi et al. 2012). This branch is...
英文别名: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase中文名: 中文别名: CBNumber: CB31333962 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 0 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase化学性质...
Here, we have developed a set of orthogonal pathways for eukaryotic O-linked protein glycosylation in Escherichia coli that installed the cancer-associated mucin-type glycans Tn, T, sialyl-Tn and sialyl-T onto serine residues in acceptor motifs derived from different human O-glycoproteins. These ...
中文名:O-SIALOGLYCOPROTEINENDOPEPTIDASE(PASTEURELLAHAEMOLYTICA),英文名:O-SIALOGLYCOPROTEINENDOPEPTIDASE(PASTEURELLAHAEMOLYTICA),CAS:,MSDS.
Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides. The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein has been shown to be extensively modified by N-linked glycosylation; however, the pre... HB Bernstein,SP Tucker,E Hunter,... -...
This chapter elaborates the structural chemistry and the biological aspects of O -sialoglycoprotein endopeptidase. The enzyme O -sialoglycoprotein endopeptidase, abbreviated as glycoprotease, derives its name from its unique specificity for the proteolytic cleavage of glycoproteins, and all known substra...
that O-mannosylation is prerequisite for the formation of FOGs, and 2) the addition of pNP-α-Man to the YPMan media did not result in the lengthening of the oligomannose structures on this compound,5 implying that elongation of O-mannosyl glycans likely occurs on the glycoprotein itself. ...