Protein O -glucosylation involves the addition of a 尾 -linked glucose to the hydroxyl group of a serine residue within an epidermal growth factor-like (EGF) repeat. EGF repeats are small protein modules found in many cell surfaces and secreted proteins, defined by the presence of six ...
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Protein O-glucosylation is a conserved post-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the C1-X-S-X-P-C2 consensus sequence. The Drosophila pr...
Protein O-glucosyltransferase 1/Rumi-mediated glucosylation of Notch epidermal growth factor-like (EGF-like) domains plays an important role in Notch signaling. Protein O-glucosyltransferase 1 shows specificity for folded EGF-like domain... Z Li,M Fischer,M Satkunarajah,... - 《Nature Communicatio...
P46CAP10-like 46 kDa protein; KDELC family like 1; KDELCL1; KTEL (Lys-Tyr-Glu-Leu) containing 1; KTEL motif-containing protein 1; KTELC1; MDS010; MDSRP; MDSRPKTELC1; MGC32995; Myelodysplastic syndromes relative protein; POGLUT1; protein O-glucosyltransferase 1; Rumi; x 010 protein...
POGLUTs/rumiencoding glucosyltransferases possess a catalytic CAP10 domain and a KDEL-like localization signal. The CAP10 protein was first discovered in aCryptococcus neoformansfungus35and most proteins with CAP10 domain also have an ER-retention signal. BLAST analysis has indicated that POGLUT1 sha...
Protein O-glucosylation is a conserved post-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the C1-X-S-X-P-C2 consensus sequence. The Drosophila protein O-glucosyltransferase (Poglut) Rumi regulates Notch signaling, but the contribution of protein O-...