We previously showed that oncogenic HRASV12 conferred tumour initiation capacity in tumour suppressor p53-deficient (p53/) primary mouse embryonic fibroblasts (MEFs) through transcription factor NF-魏B-mediated enhancement of glucose uptake; however, the underlying mechanisms of RAS oncogene-induced CSC...
英文名字 GCNT1, ID (GCNT1, NACGT2, Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, Core 2-branching enzyme, Core2-GlcNAc-transferase)供应商 MyBioSource产品货号 MBS644340产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格产品说明书 点击查看...
UDP- N -acetylglucosamine/polypeptide- N -acetylglucosaminyltransferase or O -GlcNAc transferase catalyzes the transfer of an N -acetylglucosamine moiety from the donor substrate UDP-GlcNAc onto serine/threonine residues of nuclear and cytoplasmic proteins (Torres and Hart 1984). Discovered in the ...
Fringe (UDP-GlcNAc: O-Fucosylpeptide ß1,3 N-Acetylglucosaminyltransferase)Fringe provides a clear example of the role that carbohydrate modifications can play in regulating signal transduction events. Fringe was originally identified for its role in dorsal/ventral boundaryDr. Robert S. Haltiwanger...
Fringe modulates Notch activity by altering the structure of the O -fucose glycans on the Epidermal Growth Factor-like (EGF) repeats in the extracellular domain of Notch (Bruckner et al. 2000; Moloney et al. 2000a). O -Fucose modifications occur between the second and third conserved cysteine...
The action of pig gastric mucosal UDP-GlcNAc:Gal beta 1-3(R1)GalNAc-R2 (GlcNAc to Gal) beta 3-N-acetylglucosaminyltransferase on high molecular weight substrates. the action of pig gastric mucosal UDP-GlcNAc:Galβ1-3(R 1 )GalNAc-R 2 (GlcNAc to Gal) β3-N-acetyl-glucosaminyl...
N-(1,7,8-trihydroxy-octahydroindolizin-6-yl)carboxylic acid amide derivatives as glycosidase inhibitors (O-GlcNAcse) for the treatment of allergy and asthmaThe invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical ...