Yamamoto’s assay for the successful synthesis of the mystery molecule was the increased agitation and cancer-cell-killing activities of macrophages in a Petri dish when exposed to each experimental batch. This is somewhat subjective, and vulnerable to expectations; even medieval alchemists would shake...
The functional role(s) of the association of such domains has not been investigated so far in any PGH. Moreover, the role of AST and SH3b domains remains poorly understood except for the importance of SH3b domains of PGHs for PG binding (3, 9., 10., 11.). Concerning the accessory ...
A growing body of evidence from animal model systems also suggests an important role for OGT in polycomb-dependent repression of genes activity. Moreover, O-GlcNAcylation may be a part of the histone code: O-GlcNAc residues are found on all core histones. Keywords: O-GlcNAcylation; Cancer; O...
30 years ago, the role of O-glycans was only seen in the influence of physical parameters, such as ensuring protein stability and tertiary structure, providing the basis for rigid conformations and slowing down proteolytic degradation of the peptide chain; most of specialised recognition events have...
It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood. However, the regulation of the processes and the molecular aspects of defects, ...
Finally, we will discuss the potential of activating or inhibiting ferritinophagy and ferroptosis for therapeutic purposes. Keywords: NCOA4; ferritinophagy; iron homeostasis; erythropoiesis; ferroptosis; cancer 1. Introduction Iron is required in multiple biological processes [1] including oxygen binding...