Arginyl-A-O insulin, a by-product of the biotechnological synthesis of human insulin from human proinsulin, is added to serum-free tissue culture media to stimulate the growth of mammalian cells which respond positively to insulin in tissue culture.WALTER FRANCIS PROUTY...
Recently, we have shown that a newly synthesized vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), VO(opt) 2, is a potent orally active insulin–mimetic in treating streptozotocin-induced diabetes in rats, with long-term action. In the present study, the anti-diabetic effect of...
Glucose-responsive formulations of insulin can increase its therapeutic index and reduce the burden of its administration. However, it has been difficult to develop single-dosage formulations that can release insulin in both a sustained and glucose-responsive manner. Here we report the development of ...
The two UK gas pipeline businesses sold by Total Final Elf to Star Capital , a new equity fune formed by Banco Santander Central Hispano and Royal Bank of Scotand, together constitute one of the main challengers to Transco's dominant position in the UK gas market(WGI Dec,14,p24)DOI...
FATOSTATIN A性质、用途与生产工艺 生物活性 Fatostatin (125B11) 是一种diarylthiazole的衍生物,是 Sterol regulatory element binding proteins (SREBPs) 活化的特异性抑制剂。Fatostatin 可结合SCAP (SREBP cleavage-activating protein),并抑制SREBP的ER-Golgi易位。Fatostatin 可抑制癌细胞生长并增强癌细胞的凋亡...
4.Efectividad e impacto económico de un programa de atención integrada con soporte de telemedicina a pacientes diabéticos tipo 2 tratados con insulina (estudio GITDIABE) and spring 机译:针对使用胰岛素治疗的2型糖尿病患者的远程医疗支持综合护理计划的有效性和经济影响(GITDIABE研究) Jose M. Inori...
OBJECTIVE--Pertussis toxin uncoupling-based studies have shown that Gαi and Gαo can inhibit insulin secretion in pancreatic B-cells. Yet it is unclear whether Gαi and Gαo operate through identical mechanisms and how these G-protein-mediated signals inhibit insulin secretion in vivo. Our ob...
We demonstrate that, consistent with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice. Hence, we provide a unique bioactive compound that inhibits pAmpkα disposal. Together, these results ...
A significant association between prenatal hypertrophic cardiomyopathy and fetal hyperinsulinism was demonstrated (p = 0.013). CONCLUSION: There is an association between hypertrophic cardiomyopathy and high levels of fetal insulin. 展开 关键词: Cardiomiopatía Hipertrófica Hiperinsulinismo Insulina Emba...
Zafon Llopis C. Envejecimiento y resistencia a la insulina. Ma´ s alla´ del si´ndrome metabo´ lico. Rev Esp Geriatr Gerontol. 2007;42:302-11.Carles Zafon Llopis . (2007) Envejecimiento y resistencia a la insulina. Más allá del síndrome metabólico. Revista Española de ...