求翻译:O-GlcNAcylated.是什么意思?待解决 悬赏分:1 - 离问题结束还有 O-GlcNAcylated.问题补充:匿名 2013-05-23 12:21:38 O型GlcNAcylated 。 匿名 2013-05-23 12:23:18 O-GlcNAcylated。 匿名 2013-05-23 12:24:58 O-GlcNAcylated。 匿名 2013-05-23 12:26:38 O-GlcNAcylated。
This O-GlcNAcylated protein-like substance contains at least one unit selected from the group consisting of an N-acetylglucosamine unit, carboxy group-containing radical polymerizable units, a styrene unit, a polyethyleneimine unit, a poly-L-lysine unit, and a biotin unit. This fibrosis therapeutic...
O-GlcNAcylation是癌症的一般特征,已发现源于不同部位的肿瘤包括乳房、前列腺、胰腺、肺和结肠存在O-GlcNAcylation。在胰腺导管腺癌细胞(PDAC)中,NF-κB和IKKα/IKKβ的p65亚基发生O-GlcNAcylated。通过敲除OGT来减少细胞的O-GlcNAcylation会抑制p65亚基的Ser 536上的磷酸化,进而通过损害p65的核定位和抑制其转录活性来...
O-GlcNAc 修饰异常可导致糖尿病、心血管疾病、 并伴随p27 表达的上调以及转录因子FoxM1 (forkhead box 肿瘤和阿尔茨海默病等多种疾病的发生。 protein M1)和增殖细胞核抗原 (proliferating cell nuclear antigen,PCNA )表达的下调;OGT 基因沉默还导致 2 蛋白质O-GlcNA c 糖基化与各种肿瘤 MCF-10A-ErbB2 细胞...
作者: 陈兴 摘要: O-GlcNAc(O-linked N-acetylglucosamine)modification is a non-canonical form of protein glycosylation,which occurs intracellular and is dynamically regulated.Our lab has developed chemical labeling methods that allow quantitative profiling of O-GlcNAcylated proteins and the modification...
[11] Park M J, Kim D I, Lim S K, et al. High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic
(B) 以未修饰或O-GlcNAcylated SRPK2(aa454-521)为底物的体外S6K1激酶测定。 (C) PF-4708671(一种S6K抑制剂,20mM)处理HEK293T细胞24h或BADGP(5mM)处理48h,然后用WB检测SRPK2的O-GlcNAcylation和磷酸化。 (D) 用指定的质粒转染HEK293T细胞,并分析SRPK2的O-GlcNAcylation。
3.Song H, Ma J, Bian Z, et al. Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma. Signal Transduct Target Ther. 2019;4:40. 4.Xu S, Xiao J, Yin F, Guo X, Xing L, Xu Y, Chong K. The Protein Modifications of O-GlcNAcylation and Phosphorylation Medi...
目的研究O连接的N-乙酰葡萄糖胺(O-GlcNAc)糖基化及乙酰氨基葡萄糖转移酶(OGT)对Nalm-6细胞生物学行为及对依托泊苷(Vp16)诱导凋亡的影响。 方法利用OGT抑制剂Alloxan构建低O-GlcNAc修饰的Nalm-6细胞模型,CCK-8法检测Alloxan对细胞增殖的影响,流式细胞术检测Alloxan对细胞凋亡及细胞周期的影响;以不同浓度的Vp16处...
此文档收集于网络,如有侵权请联系网站删除此文档仅供学习和交流摘要摘要O.GlcNAc是广泛存在于蛋白质丝/苏氨酸残基上的一种动态、可逆的蛋白翻译后修饰。研究表明,O.GlcNAc修饰与神经退行性疾病、糖尿病、癌症等许多疾病密切相关。O.GlcNAc修饰过程由Ⅳ-乙酰氨基葡萄糖转移酶(OGT)和Ⅳ.乙酰氨基葡萄糖苷酶(OGA)共同调节...