Any effect of NXY-059 on hemostasis may be important when treating stroke patients. This phase I randomized, double-blind, placebo-controlled, 3-period crossover study compared the effect of NXY-059, desmopressin, and placebo on bleeding time, platelet aggregation, and adhesion in 30 healthy ...
Acute ischemic stroke patients receiving NXY-059 may also be exposed to diuretics for treatment of heart failure or hypertension. NXY-059 and furosemide are partly eliminated by active tubular secretion via an organic anion transporter. This double-blind, randomized, crossover, placebo-controlled ...
动物实验证实,自由基捕获剂NXY-059能缩小急性脑缺血的梗死体积并改善神经 功能,是一种符合卒 中治疗学术产业圆桌会议(StrokeIherapyAcademicIndustryRoundtable,STAIR)标准 的神经保护剂.据最近的 NEnglJMed报道,急性缺血性卒中后早期给予NXY-059能显着改善患者转归. 急性缺血性卒中NXY治疗(Stroke—AcuteIschemicNXYTreatme...
的神经功能和不良反应情况。结果认为,NXY.059能被急性 缺血性中风病人良好耐受,2个剂量组的血药浓度稳态值分 别为25和45band/L,清除率为4.6【/h。 名为SAINTI(StrokeAcuteIschemlcNXY059Treatment) 的Ⅲ期临床实验数据表明,NXY-059对缺血性中风造成的神 ...
Any effect of NXY-059 on hemostasis may be important when treating stroke patients. This phase I randomized, double-blind, placebo-controlled, 3-period crossover study compared the effect of NXY-059, desmopressin, and placebo on bleeding time, platelet aggregation, and adhesion in 30 healthy ...
摘要: 动物实验证实,自由基捕获剂NXY-059能缩小急性脑缺血的梗死体积并改善神经功能,是一种符合卒中治疗学术产业圆桌会议(Stroke Therapy Academic Industry Roundtable,STAIR)标准的神经保护剂.据最近的N Engl J Med报道,急性缺血性卒中后早期给予NXY-059能显著改善患者转归.关键词:...
NXY-059 for acute ischemic stroke. N Engl J Med. 2006;354:588 - 600.Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, Grotta J, Lyden P, Shuaib A, Hardemark HG, Wasiewski WW; Stroke-Acute Ischemic NXY Treatment (SAINT I) Trial Investigators. NXY-059 for acute ...
S A N F R A N C I S C O -- In the largest ran- domized acute stroke neuroprotection tri- al to date, the investigational free-radical trapping neuroprotectant NXY-059 failed to provide any benefit over placebo for improving stroke outcomes, despite promising data from an earlier trial,...
NXY一059是阿斯利康公司新近研制的一种抗自由基药物。 它的化学名为N一(叔丁基)一a,2,4一二磺酸基苯基硝酮二钠盐 (disodium2,4-disulfophenyl—N—tert—butylnitrone),是一种硝酮 类化合物,具有较强的捕获自由基的能力,一旦其与自由基结 合形成一种稳定的新的化合物(spinadduct),此时自由基即失 ...
CeeTox Analysis of CNB-001 a Novel Curcumin-Based Neurotrophic/Neuroprotective Lead Compound to Treat Stroke: Comparison with NXY-059 and Radicut 来自 学术范 喜欢 0 阅读量: 45 作者:PA Lapchak,James M. McKim Jr. 摘要: In the present study, we used a comprehensive cellular toxicity (CeeTox...