Here we study crystal formation of DNA-linked NP using a coarse-grained molecular model in which ss-DNA are attached to spherical core NP. We examine the effect of strand number on crystal stability by using the method of thermodynamic integration to compute the free energy and entropy of BCC...
The nuclease introduces single-strand nicks into calf thymus DNA and degrades the DNA to a discrete size. Native DNA incubated with the nuclease averages 7S in alkaline sucrose gradients; denatured DNA incubated with the nuclease is largely 3S.Er-Chung...
The γH2Av signal is unlikely due to spreading in response to double-strand breaks, given that spreading occurs bidirectionally from the break site and would extend beyond underreplicated boundaries (Berkovich et al., 2007, Iacovoni et al., 2010, Kim et al., 2007, Rogakou et al., 1999,...
Linking Numberdoi:10.1007/978-1-4020-6754-9_9457A linking number indicates the number of times one strand of DNA double helix crosses over the other strand in space. The linking number may reflect the degree of supercoiling in a closed DNA...Springer Netherlands...
Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replic
If a DNA strand contains 20% guanine, then how much will be adenine? How many bases are present on a strand of mRNA with 25 codons? Assume that there are approximately 3,000,000,000 base pairs in the mammalian genome (genes constitute only a small portion of t...
has been associated with increased risk of malignancy because immunosuppressive agents impair the normal immunosurveillance mechanisms that would detect malignant cells, and CsA has been shown to induce double-strand DNA breaks and inh 您的答复是“CNI疗法,特别是高曝光长时期的时期,同敌意联系在一起的增...
Strand displacement amplification This invention relates a nucleic acid target amplification and detection method which operates at a single temperature and makes use of a polymerase in conjunction with an endonuclease that will nick the polymerized strand such that the ... GT Walker - US 被引量: ...
The other cell lines were paired-end sequenced to 76, 78, 100 or 108 bp read-length in a strand-specific manner (1182-4H, D16-c3, D17-c3, D20-c5, D4-c1, D8, D9, Kc167, L1, mbn2, S1, S2R+, S3, Sg4, and W2). Previous modENCODE datasets ChIP-chip datasets were from ...
However, the distribution of complex DNA alterations and its relation to gene expression in tumors have not been characterized in ESCC. ESCC is a common malignancy worldwide and one of the most common cancers in the Chinese population; Shanxi Province in north central China has some of the ...