VENTILATION/PERFUSION LUNG IMAGING IN PULMONARY EMBOLISM: ANALYSIS WITH CONSIDERATIONS OF SIZE, NUMBER OF SEGMENTS AND CHEST X-RAY.: E2doi:10.1097/00003072-198309009-00028Ramanna, LalithaWaxman, Alan D.Brachman, Michael B.Kaushik, DhanaJulien, Peter...
We investigated the landscape of different types of alterations affecting driver genes in 17,644 cancer exomes and genomes. We find that oncogenes may simultaneously exhibit signatures of positive selection and also negative selection in different gene segments, suggesting a method to identify additional...
resulting in 28,245,162 CpG sites. Segments containing three or more contiguous CpGs with a neighboring distance within 100 bp and having analyzable coverage (median coverage at each CpG site in the healthy training cohort, >3×) were identified. Segments longer than 1000 bp were...
Somaticcopy-number aberrations(CNAs) are frequent genetic alterations in cancer that increase or decrease the number of copies of relatively large genomic segments. CNAs range in size from focal events affecting hundreds to thousands of nucleotides, to gain and loss of chromosome arms or whole chromo...
of positive integer copy numbers across chromosomes (here: two chromosomes with four segments each). To infer the correct MED, LOH events are considered first as lost segments cannot be re-gained by later events. WGD events span the full copy-number profile, whereas gain and loss events can ...
Single haplotype assembly of the human genome from a hydatidiform mole 117 被引用·0 笔记 引用 Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma 131 被引用·0 笔记 引用 TSC/MTOR-associated Eosinophilic Renal Tumors Exhibit a Heterogeneous Clinicopathologic Spectrum ...
Copy number segments were obtained from the circular binary segmentation (CBS) algorithm [47] implemented in R package DNAcopy using default settings. Gene expression profiling Affymetrix GeneChip Human Gene 1.0ST Array was used for gene expression analysis according to the protocols from the ...
Changes in DNA copy number are one of the hallmarks of the genetic instability common to most human cancers. Previous micro-array-based methods have been used to identify chromosomal gains and losses; however, they are unable to genotype alleles at the level of single nucleotide polymorphisms (SN...
Fig. 1: ENSA is amplified at the 1.21.3 region, is highly expressed and predicts poor survival in TNBC. Full size image ENSA promotes the growth of TNBC cells Fig. 2: ENSA is a major driver of TNBC cell growth. Full size image ...
Each SCNA was characterized by its length, amplitude, genomic position and, when determinable, allele and the timing of its generation relative to neighboring segments. We deconstructed each chromosome individually into two sequential steps (to be described in greater detail; T.I.Z., J.W., S...