Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study, we provide a direct measurement of the number of genes in human and mouse. We have taken advantage of the fact that many mammalian genes are associated with CpG...
Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis 28, 1442–1445 (2007). CAS PubMed Google Scholar Lupski, J. R. Genomic disorders: structural features of the genome can lead to DNA rearrangement and human disease traits. Trends ...
Behavioral and Brain Functions 2010, 6:40 http://www.behavioralandbrainfunctions.com/content/6/1/40 RESEARCH Open Access Copy number variation of the SELENBP1 gene in schizophrenia Shirly Amar1, Ofer Ovadia2, Wolfgang Maier3, Richard Ebstein4, RH Belmaker1, Dan Mishmar2*, Galila Agam1* ...
Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of theSOX9gene (RevSex) and duplication of theSOX9gene (also observed...
A Note on the Variance of the Number of Loci Having a Given Gene Frequency In a recent not in this journal (MARUYAMA 1973), one of us has considered, for a certain genetic model, the variance of the distribution of the number of loci having a given gene frequency. The formula given ...
The proposed stability-based approach for estimating the number of cell types is implemented in an R package and is freely available from (https://github.com/PYangLab/scCCESS).Background Single-cell RNA-sequencing (scRNA-seq) has emerged as a key technology for profiling the gene expression ...
The study of the PIGY gene in sheep is still in the early stage. However, sequencing analysis has revealed that the CNV of the PIGY gene overlaps with 28 QTL that are related to sheep economic traits like muscle density and carcass weight. Thus, the PIGY may be a key gene influencing...
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To associate genes contained in CNVRs with phenotypes, we converted 560 bovine Ensembl gene IDs to their 438 orthologous associated mouse gene IDs, and 195 of these mouse orthologous genes were categorized into 1,627 phenotypes in the Mouse Genome Informatics (MGI) database. We identified 861 ...
The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individua...