There are four stages of mitosis: prophase, metaphase, anaphase and telophase.1) Prophase: chromatin into chromosomes, the nuclear envelope break down, chromosomes attach to spindle fibres by their centromeres 2) Metaphase: chromosomes line up along the metaphase plate (centre of the cell) 3)Anap...
It has previously been suggested that cancerous transformation may result in a shorter cell cycle =-=(34)-=- and, therefore, in a larger number of cell divisions. However, it is important to note that growth of a tumor cell population does not necessitate shortening of the cell cycle, ...
Topoisomerase IIα (Topo IIα) and the centromere-specific histone H3 variant CENH3 are key proteins involved in chromatin condensation and centromere determination, respectively. Consequently, they are required for proper chromosome segregation during cell divisions. We combined two super-resolution techni...
Structural rearrangements of the genome resulting in genic imbalance due to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines and tumors, where they may be an advantage to cells. In order to explore the biological consequences of copy numbe...
chromosomes, hence gametes have half the diploid number of the human somatic cells. Two cells after fertilization fuse forming a zygote now with two sets of chromosomes. Then the zygote develops to grow through mitosis. This chromosome number of 46 in humans for each somatic cell gets maintained...
It has previously been suggested that cancerous transformation may result in a shorter cell cycle =-=(34)-=- and, therefore, in a larger number of cell divisions. However, it is important to note that growth of a tumor cell population does not necessitate shortening of the cell cycle, ...
cell fusionmulti-daughter divisionwogonin5-fluorouracilMultipolar mitosis was observed in cancer cells under mechanical stress or drug treatment. However, a comprehensive understanding of its basic properties and significance to cancer cell biology is lacking. In the present study, live-cell imaging was ...
MitosisPeaRoot-knot nematodeGiant cells induced by Meloidogyne sp. are characteristically enlarged and multinucleate. Each nucleus has more chromosomes than unaffected root tip cells. In Vicia faba, only euploid nuclei were detected (Huang & Maggenti, 1969) whereas in Pisum sativum euploid and ...
Moreover, the minimum value in the Adult 1–3 and Senile groups is even less than that in Children, suggesting that the low-copy cells are produced from high-copy parental cells rather than retained through a series of cell divisions in a minor fraction of subjects who have avoided strong ...