Chemotherapy is an effective way to improve the prognosis of colorectal cancer patients, but patient resistance to chemotherapeutic agents is becoming a major obstacle to treatment. Nucleotide metabolism correlates with the progression of colorectal canc
The evolution of bat nucleic acid-sensing Toll-like receptors Mol. Ecol., 24 (2015), pp. 5899-5909 CrossrefView in ScopusGoogle Scholar [94] J. Pohar, D. Lainšček, R. Fukui, C. Yamamoto, K. Miyake, R. Jerala, M. Benčina Species-specific minimal sequence motif for oligodeo...
Nucleotide sequences coding polypeptide for use in the treatment of cell proliferative, tumor, nervous system, arthritis, graft-versus-host disease, stroke, psoriasis and inflammatory bowel diseasedoi:US20030049733 A1The present invention is directed to novel polypeptides and to nucleic acid molecules ...
G-quadruplexes (G4s) are stranded secondary structures of nucleic acids rich in guanine. These nucleic acid sequences are characterized by four runs of at least three guanines separated by short loops, which can potentially fold into an intramolecular or intermolecular G4 structure [1]. The guan...
Protein-nucleic acid interactions/Folding and binding CristinaFerrer-Orta, ...NuriaVerdaguer, inCurrent Opinion in Structural Biology, 2006 The nucleotide-binding site of thePV3Dpolymerase.(a)The network of interactions, involving the buriedN terminusof PV 3D polymerase (PDB code 1RA7), that drive...
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Nucleic acid-based drugs for patients with solid tumours Article 08 April 2024 Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro Article Open access 23 February 2023 Integrase-derived peptides together with CD24-target...
Despite its known role as a secreted neuroprotectant, much of the mesencephalic astrocyte-derived neurotrophic factor (MANF) is retained in the endoplasmic reticulum (ER) of producer cells. There, by unknown mechanisms, MANF plays a role in protein foldi
Middle: histogram of the number of amino acid mismatches in the HVR within the 77 pairs. Bottom: histogram of the differences in length in the HVR within the 77 pairs. (B) Scatterplot of the amino acid mismatches in the PSD region versus mismatches in exon 8. The...
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