high sensitivities could be achieved, and the methods could be applied to the analysis of many kinds of biological samples (cells, tissues, plants, bacteria,etc.). Developing new analyzing techniques may help the utilization of nucleotides and nucleotide sugars in the diagnosis and therapy of disea...
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Glycoproteins and lipids in the Golgi complex are modified by the addition of sugars. In the yeast Saccharomyces cerevisiae, these terminal Golgi carbohydr... XD Gao,A Nishikawa,N Dean - 《Journal of Biological Chemistry》 被引量: 112发表: 2001年 Crystal Structure of a B-Form DNA Duplex Cont...
Since the isolation and characterization of cAMP in early 1957, several enzymatic and chemical synthetic procedures have been developed to provide cAMP and various cyclic nucleotide analogs. The synthesis of cAMP and 2′-deoxy-cAMP by bacterial fermentat
In addition, these estimates have not included the consumption of NSs towards glycolipid synthesis. Here, we present a theoretical framework to estimate the demand of all nucleotide sugars consumed towards CHO HCP N-linked and O-GalNAc glycosylation, as well as for glycolipid synthesis. Our ...
- 《Nature Chemical Biology》 被引量: 120发表: 0年 Assignment of Biochemical Functions to Glycosyl Transferase Genes Which Are Essential for Biosynthesis of Exopolysaccharides in Sphingomonas Strain S88 and... Glycosyl transferases which recognize identical substrates (nucleotide-sugars and lipid-linked ...
Suraj Unniappan, in Advances in Protein Chemistry and Structural Biology, 2019 9 NUCB protein-protein interactions that mediate different physiological functions Physical interactions with other proteins can provide important insights into a protein's function and regulation. Human NUCB1 and NUCB2 form ...
nucleotide sugars in glycosylation, two methods for monitoring nucleotide sugar metabolism, namely, ion-pair reversed-phase HPLC and LC-MS, have been previously described (Nakajima et al., Glycobiology 20(7):865–871, 2010; Mol Cell Proteomics (9):2468–2480, 2013). Using the HPLC method, ...
CarmenAvendaño,J. CarlosMenéndez, inMedicinal Chemistry of Anticancer Drugs, 2008 1.1General features of ABC efflux pumps ABC transportersare ‘pump’ proteins found in the membranes of bacteria and human cells. They are present in organs related to digestion and excretion as a protective mechanis...
El Kouni, in Recent Advances in Nucleosides: Chemistry and Chemotherapy, 2002 4 Transport of purines As mentioned above, transport across the cell membrane is the first step in the salvage pathways of exogenous purines by parasites. An understanding of the mechanisms of transport and membrane ...