Nucleoside 2-deoxyribosyltransferase catalyzes cleavage of a 2′-deoxyribosylnucleoside (A) to a nucleobase (P) with deoxyribosylation of the enzyme. Substrates quenched the intrinsic fluorescence of native enzyme () and a catalytically inactive mutant enzyme (E98A enzyme). The time courses of ...
used a crystallographic approach to show that nicotinamide phosphoribosyltransferase (NAMPT), an enzyme that recycles nicotinamide to NAD+, couples ATP hydrolysis with formation of 1-pHis on H247 that dramatically increases catalytic activity [37]. Other enzymes that rely on pHis intermediates ...
A pyrimidine deoxynucleoside phosphorylase, which also possessed deoxyribosyltransferase activity, was purified about 89-fold from trout liver with an average recovery of 67%. Starch-gel electrophoresis showed that four proteins were present, one of which possessed both activities. The phosphorylase utiliz...
Enzymatic Synthesis of Therapeutic Nucleosides using a Highly Versatile Purine Nucleoside 2'‐DeoxyribosylTransferase from Trypanosoma brucei The use of enzymes for the synthesis of nucleoside analogues offers several advantages over multistep chemical methods, including chemo‐, regio‐ and ster... P Elen...
Little enzyme activity was retained by entrapment in K-carrageenan. N-deoxyribosyltransferase immobilised on PAN was used to prepare 2′-deoxy-2-thiouridine.doi:10.3109/10242429409034372Nicola HicksDavid W. HutchinsonTaylor & FrancisChemInformHicks N, Hutchinson DW (1994) Synthesis of nucleoside analogs ...
Addition of ethylene glycol (10% v/v) has a beneficial effect on the synthesis of 2-deoxynucleosides catalysed by crude preparations of N-deoxyribosyltransferases from Lactobacillus leichmannii. In the absence of added organic solvent decomposition of products and starting materials by deamination or...
Purine nucleoside phosphorylase, Purine nucleoside:orthophosphate ribosyltransferase; Nucleoside Phosphorylase from microorganisms; PNP/Purine-nucleoside phosphorylase; Purine deoxynucleoside phosphorylase; Purine deoxyribonucleoside phosphorylase; Purine nucleoside phosphorylase [ >=200 units/mg]; Purine ribonucleoside ...
Phosphodeoxyribosyltransferases, Designed Enzymes for Deoxyribonucleotides Synthesis A large number of nucleoside analogues and 2'-deoxynucleoside triphosphates (dNTP) have been synthesized to interfere with DNA metabolism. However, in vivo... PA Kaminski,G Labesse - 《Journal of Biological Chemistry》...
EC 2.4.2.1; FLJ94043; FLJ97288; Inosine phosphorylase; MGC117396; MGC125915; MGC125916; NPFLJ97312; nucleoside phosphorylase; PNP; PRO1837; PUNP; purine nucleoside phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase Product Datasheets ...
2) Trans-N-deoxyribosylase N-脱氧核糖转移酶3) ADP ribosyltransferase ADP核糖基转移酶4) transformed [英][træns'fɔ:m] [美][træns'fɔrm] 磷酸核糖转移酶 例句>> 5) ADP-ribosyltransferase ADP-核糖转移酶6) poly(ADP-ribose) polymerase (PARP) ADP核糖转移酶类...