phospholipidsFTIR spectroscopyhydrationhigher order structuresWe used FTIR spectroscopy to comparatively study the hydration of films prepared from nucleic acids (DNA and double-stranded RNA) and lipids (phosphatidylcholines and phosphatidylethanolamines chosen as the most abundant ones) at room temperature ...
Phospholipids - They make up only about 2 percent of dietary lipids. They are water-soluble and are found in both plants and animals. Steroids - They are the least common type of lipid. Cholesterol is the most common steroid. It is an important component of the cell membrane and...
Lipids: organic compounds that include fats, phospholipids, steroids, and waxes.
LNP is a combination of ionizable lipids, cholesterol, phospholipids, and polyethylene glycol. The presence of cholesterol and phospholipids in LNP improves the stability of mRNA, while polyethylene glycol prevents mRNA from binding to plasma proteins, thereby increasing its circulation. This plays a ...
(bare iron oxides, silica-coated or easily-functionalized surfaces) and the main groups of biomolecules: proteins, lipids, nucleic acids and carbohydrates. Special attention is devoted to the driving forces and interdependencies responsible of interactions at the solid-liquid interface, to the unique ...
The present disclosure relates to ionizable lipids and its compositions for nucleic acid delivery, belonging to the field of medicinal chemistry. BACKGROUND Nucleic acid drugs include DNA, antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), microRNAs (miRNAs), miRNA mimics, antimiRs,...
aqueous core, while hydrophobic drugs are enclosed within the lipophilic bilayer shell. Due to the fundamental role of lipids and phospholipids in cell membranes, liposomes share a similar structure to biological cells, resulting in excellent biocompatibility and facilitating cellular uptake of RNA [71,...
biomolecules, including proteins, nucleic acids, lipids, and carbohydrates (reviewed in Szabo et al., 1995; =-=Raghavan and Bjorkman, 1995-=-; van ... M Raghavan,PJ Bjorkman - 《Structure》 被引量: 73发表: 1995年 Spectroscopy of Biological Molecules: Modern Trends This is a volume that...
Labeling Oligonucleotides and Nucleic Acids—Section 8.2 Table 8.6 Molecular Probes nucleic acid labeling kits. FluorophoreEx/Em *Similar DyesULYSIS Nucleic Acid Labeling KitsARES DNA Labeling KitsFISH Tag DNA Kits †FISH Tag...
LNPs can be engineered to have both a core and a shell (e.g., EnCore®). The core consists of selected cationic lipids lipoplexed with nucleic acids, while the shell incorporates helper lipids and cholesterol and polyethylene glycol chains. The strategic design is that ...