ribonucleic acid,RNA- (biochemistry) a long linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell; "ribonucleic...
The two main classes of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the master blueprint for life andconstitutesthe genetic material in all free-living organisms and mostviruses. RNA is the genetic material of certain viruses, but it is also found in all...
as vectors fornucleic acid delivery. For example, MS2 VLPs have been developed to deliver the antisense RNA. Antisense RNA was packaged by simple co-expression of two different plasmids in anE. coliexpression system. After isolation, MS2 VLPs were chemically modified to conjugate to the human imm...
RNA,ribonucleic acid, is composed of phosphate, a sugar -- ribose -- and the bases adenine, uracil, cytosine and guanine. Though typically located in the cytoplasm of the cell, RNA is usually produced in the cell’s nucleus. Three major types of RNA are found in cells: messenger RNA (m...
A large reduction in the relative activity of nuclease might have obtained had the nucleic acid been added to the clay–enzyme system. In investigating the interactions of DNA and RNA with acid-washed clay minerals (illite, kaolinite, montmorillonite), Goring and Bartholomew (1952) found that ...
Nucleic acid detection powered by CRISPR technology provides a rapid, sensitive, and deployable approach to molecular diagnostics. While exciting, there remain challenges limiting its practical applications, such as the need for pre-amplification and the
The first unlocked nucleic acid (UNA) monomer was described more than a decade ago, but only recent reports have revealed the true potential applications of this acyclic RNA mimic. UNA monomers enable the modulation of the thermodynamic stability of various nucleic acid structures such as RNA and...
RNA(mRNA),ribosomal RNA(rRNA), and a series ofnoncoding RNAs(ncRNAs).PCRis widely used fornucleic acid amplificationfor detection and identification in current molecular diagnostic laboratory. This is because the technique can be employed to evaluate not only the degree of gene expression in...
RNA in a target organism. Once a probe hybridizes with its target sequence, it forms a stable double-stranded molecule with its target sequence and signals detection through the use of a reporter molecule[2]. Compared with conventional culture-based methods alone,nucleic acidprobes can identify ...
Nucleic acids, such as DNA and RNA as well as a number of nucleic acid analogues such as PNA, HNA, MNA, ANA, LNA, INA, CNA, CeNA, TNA, (2′-NH)-TNA, (3′-NH)-TNA, α-L-Ribo-LNA, α-L-Xylo-LNA, β-D-Xylo-LNA, α-D-Ribo-LNA, [3.2.1]-LNA, Bicyclo-DNA, 6-Amino-...