Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain functionnuclear miRNAmicrogliamiR-137Pu.1Jdp2neurodevelopmenttranscriptionchromatinMicroglia are versatile regulators in brain development and disorders. Emerging evidence links microRNA (miRNA)-mediated regulation to ...
et al. The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation. Life Sci. Alliance 3, e201900494 (2020). Article PubMed PubMed Central Google Scholar Singhania, R. et al. Nuclear poly(A) tail size is regulated by Cnot1 during the serum response. Preprint at bioRxiv ...
and H3K27ac ChIP-seq peak data were obtained fromhttp://www.cistrome.orgvia projectGSM1463433. IMMGEN RNA-seq count data were fromGSE124829. Human B-ALLNCOR1andNCOR2mutation and RNA-seq data were obtained from St Jude ProteinPaint (https://pecan.stjude.cloud/proteinpaint).Source dataare...
The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunol Rev, 2017; 277, 113−27. [16] Dresselhaus EC, Meffert MK. Cellular specificity of NF-κB function in the nervous system. Front Immunol, 2019; 10, 1043. [17]...
J. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21, 1393–1403 (2001). Article CAS PubMed PubMed Central Google Scholar Ryffel, G. U. Mutations in the human genes encoding the ...
A. Mechanotransduction and extracellular matrix homeostasis. Nat. Rev. Mol. Cell Biol. 15, 802–812 (2014). Article CAS PubMed PubMed Central Google Scholar Schreiber, T. H., Shinder, V., Cain, D. W., Alon, R. & Sackstein, R. Shear flow-dependent integration of apical and sub...
A region within the nucleus where ribosomal RNA transcription, processing and assembly occur. Senescence The cellular state in which cells permanently exit the cell cycle but do not undergo cell death. Autophagy A process in which cellular material is recycled following degradation by the lysosome or...
The available evidence suggests that the nuclear Nestin regulates the homeostasis of nuclear lamina and involves in the tumor cellular senescence. Methods Ethics statement BALB/c nude mice were purchased from Beijing Vital River Laboratory. Animal protocols were approved by the Ethical Committee of Sun...
cellularhomeostasis(Esteller, 2011) and one human specific variant that affects the structure of the normal brain (Chen et al., 2013), longnoncoding RNAs(lncRNAs) that affect such processes asdosage compensationandgenomic imprinting(Fatica and Bozzoni, 2014), and piwi-interacting RNA that ...
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development 141, 1614–1626 (2014). Article CAS PubMed Google Scholar Pajtler, K. W. et al. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for ...