MutationSteroid and nuclear receptor coactivators (NCoAs) have been implicated in the regulation of nuclear receptor function by enhancing ligand-dependent transcriptional activation of target gene expression. W
Nuclear Receptor Structure: Dynamics and Function 3Steroid receptor coactivator (p160) family 3.1Structural domains of SRC (p160) proteins As mentioned previously, SRC-1 was the first identifiedNRcoactivator and is the founding member of the SRC family. It was discovered in a yeast two-hybrid sc...
Ligand binding induces a conformational change that results in the dissociation of corepressors and the recruitment of coactivators, such as peroxisome proliferator-activated receptor coactivator 1 and the cAMP response element-binding protein-binding protein–p300 [5–7]. The specificity of the ...
et al. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol. Cell. Biol. 20, 6138–6146 (2000). Article CAS PubMed PubMed Central Google Scholar Fraschilla, I. & Jeffrey, K. L. The speckled protein (SP) family...
The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression. Development 127, 703–712 (2000). Article CAS PubMed Google Scholar Haider, N. B. et al. Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell ...
[89,90,91]. ERRα has long been thought to not require an endogenous ligand, because it is activated by the transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α), which is necessary for postnatal cardiac mitochondrial biogenesis [92,93,94]...
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a tran...
Peroxisome proliferator-activated receptor γ coactivator 1α iPSC: Induced pluripotent stem cell DPR: Dipeptide repeat protein SOD1: Superoxide dismutase 1 ALS: Amyotrophic lateral sclerosis FTD: Frontotemporal dementia FUS: Fused in sarcoma TDP43: ...
Alternatively, it has also been suggested that ORF1p may act as an AR coactivator in prostate cancer cells, driving growth and survival [28]. While evidence suggests that LINE-1 protein expression and retrotransposition may play a role in tumor initiation and progression, many questions remain ...
NR, Nuclear Receptor, CoR, Corepressor, CoA, Coactivator, NRE, nuclear receptor response element, ● histone deacetylase, ○ histone transdecetylase. Many of the NRs bind to a wide variety of structurally diverse DNA response elements as either monomers or homodimers.4 However, some NRs such ...