However, the function of the Farnesoid X receptor (FXR), a member of the NR family, in regulating bone homeostasis remains incompletely understood. In this study, in vitro and in vivo models revealed delayed bone development and an osteoporosis phenotype in mice lacking FXR in bone marrow ...
pregnane X receptorvan de Winkel A, van Zoest K P M, van Dekken H, Moons L M G, Kuipers E J & van der Laan L J W (2011) Histopathology58, 246–253 Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in ...
3.1. Farnesoid X receptor The Farnesoid X Receptor (FXR) mostly refers to FXR-α (NR1H4), since FXR-β (NR1H5) is a functional NR only in rodents and appears as nothing but a pseudogene in the human genome. [46,47] FXR is the bile acid sensor of enterohepatic tissues and plays a...
Schlüter T, Kinzel O, Krol HD, Deuschle U, Burnet M, Levi M, Schmitz G, Miyazaki M, Kremoser C (2012) Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer ...
The farnesoid X receptor (FXR/Nr1h4) is a critical transcriptional regulator for genes involved in bile acid processing, as well as lipid and glucose metabolism. However, very little is shown regarding the role of FXR in modulating the transcription of other nuclear receptors (NRs) that ...
Pharmacological Activation of the Bile Acid Nuclear Farnesoid X Receptor Is Feasible in Patients with Quiescent Crohn's Colitis , F.D.M., et al., Pharmacological Activation of the Bile Acid Nuclear Farnesoid X Receptor Is Feasible in Patients with Quiescent Crohn's Colitis. ... SFDM Van,RM ...
(HNF4α), HNF4γ, farnesoid X receptor (FXR), liver X receptor alpha (LXRα), LXRβ, neuron-derived orphan receptor 1, nerve growth factor-induced clone B, Nur-related factor 1, peroxisome proliferator-activated receptor alpha (PPARα), PPARγ, PPARδ, pregnane X receptor (PXR), Rev-...
Finally, there are a number of other nuclear receptors that are potential regulators of lipid homeostasis including the Farnesoid X Receptor (FXR), though not present at detectable levels via qPCR in human RPE cells (Dwyer et al., 2011), that may be important to investigate in the posterior ...
The farnesoid X-activated receptor (FXR; NR1H4) is a member of the nuclear hormone receptor superfamily and functions as a heterodimer with the 9--retinoic... Laffitte,A B. - 《Journal of Biological Chemistry》 被引量: 809发表: 2000年 A Pathway Involving Farnesoid X Receptor and Small Het...
Farnesoid X receptor (FXR) The Farnesoid X receptor (FXR), also known as bile acid receptor, is a NR activated by bile acids. FXR regulates bile acid synthesis, conjugation, and transport, as well as various aspects of lipid and glucose metabolism [226]. Recent evidence shows that FXR is...