Nuclear dense fine speckled (DFS) pattern, a competent-level pattern evaluated by the ICAP previously (AC-02),2 is frequently discussed in the current recommendation for it being the pattern best associated with apparently healthy individuals, or negatively correlating with systemic autoimmune rheumatic...
Anti-cell ANA: Antinuclear antibody ASC: Autoantibody Standardization Committee ICAP: The International Consensus on Antinuclear Antibody Patterns IIF: Indirect immunofluorescence EASI: European Autoimmunity Standardization Initiative DFS: Dense fine speckled ENA: Extractable nuclear antigens ...
Basu A, Woods-Burnham L, Ortiz G, Rios-Colon L, Figueroa J, Albesa R, et al. Specificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2. Clin Immunol 2015; 161: 241- 250....
The most common immunofluorescence pattern was a fine dense speckled pattern. In the ANA-positive patients with malignant lesions, seven had positivity for ENA profile (three for anti-RNP and anti-Sm, one for just anti-RNP, two for anti-Ro and anti-La e two for just anti-La). It was ...
Ab reactivity to at least 1 antigen was found in 20.4% psoriatic disease patients (25.7% Ps and 15% PsA) compared to 8% HCs (p=ns), the most frequent being against dense fine speckled 70 (DFS70) (6.5%). In Ps and PsA patients with secukinumab-induced remission, anti-DFS70 and ...
samples with positive ANA patterns were centromere 91%, Topo I-like 83%, speckled 66%, homogeneous with other ANA patterns 53%, speckled with other ANA patterns 53%, homogeneous 45%, nucleolar 30%, nuclear dots 28%, nuclear envelope 15%, and dense fine spec...
The model adopted a deep learning architecture with 21 layers and ANA images were used to train to detect speckled, homogenous, nucleolar, centromere, dense fine speckled, cytoplasmic and mitochondrial patterns. The data were collected from rheumatology patients from June 2016 to October 2017. We ...