Nuciferine (NF) is a high-quality aporphine alkaloid present in lotus leaf. Unlike the chemical drugs, NF elicits anti-obesity, anti-dyslipidemia, anti-hyperglycemic, anti-hypouricemic, anti-inflammatory, and anti-tumor effects, and affinity to neural receptors, and protection against obesity-...
从药理机制看，其平面结构能够嵌入DNA双螺旋，这种作用方式与某些抗肿瘤药物类似。动物实验表明，对多巴胺受体的亲和力与分子中氮原子的空间排布密切相关，调整侧链长度可改变这种相互作用强度。在抗炎作用方面，特定羟基的存在显著影响NF-κB信号通路的调控能力。现有研究存在若干争议点，例如关于主要活性位点的认定，不同...
Nuciferine (NF), extracted from the leaves of N. nucifera Gaertn, has been shown to exhibit anti-tumor and anti-viral pharmacological properties. It can also penetrate the blood brain barrier (BBB). However, the mechanism by which NF inhibits glioblastom
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摘要: Nuciferine (NF) is one of the main aporphine alkal 关键词:nuciferine folium nelumbinis metabolites UFLC-MS MS 年份: 2016 收藏 引用 批量引用 报错 分享 求助全文 通过文献互助平台发起求助,成功后即可免费获取论文全文。 请先登入相似文献 参考文献 引证文献A sensitive liquid chromatography–tandem...
Moreover, the imbalanced gut microbial structure of the model could be reversed by NF. Importantly, NF enriched the abundance of Akkermansia, resulting in its anti-hyperlipidemic activity [163]. Meanwhile, in HFD-fed rats, NF played an anti-obesity role by restoring the diversity and potential ...
Recently, nuciferine (NF), one of N. nucifera Gaertn leaf extracts has been shown to possess several pharmacological properties, including anti-viral and anti-cancer. The aim of this study is to investigate the underlying molecular mechanism of the anti-cancer activity of NF in NSCLC progression...
Nuciferine (NF), one of the main and effective components in Nelumbo nucifera Gaertn. leaf extracts, is a promising drug candidate for the treatment of obesity‐related diseases, while metformin is a first line therapeutic drug for type 2 diabetes mellitus. Since nuciferine and metformin are ...
BackgroundNuciferine (NF), extracted from the leaves of N. nucifera Gaertn, has been shown to exhibit anti-tumor and anti-viral pharmacological properties. It can also penetrate the blood brain barrier (BBB). However, the mechanism by which NF inhibits glioblastoma (GBM) progression is not ...
NF-kappa BNuciferine, a bioactive component extracted from the lotus leaf, has been reported to have various anti-inflammatory effects. In the present study, we aimed to investigate the anti-inflammatory effects and mechanism of nuciferine on lipopolysaccharide (LPS)-stimulated BV2 microglia cells. ...