美泊利单抗抑制IL-5的活性,减少重度嗜酸性粒细胞性哮喘(SEA)患者的急性加重频率并维持口服糖皮质激素(OCS)剂量。 这是一篇于2022年在《J.Pers.Med.》杂志上发表的题为“Mepolizumab for chronic rhinosinusitis with nasal polyps(CRSwNP):Treatment efficacy by comorbidity and blood eosinophil count”的文章,该文章...
Your doctor can give you blood testing that measures your eosinophil count. In clinical studies, the eosinophil blood test helped identify patients whose asthma was more likely to respond to treatment with NUCALA. Your blood test results may help your doctor diagnose you with severe eosinophilic ast...
Greater blood eosinophil count was predictive of exacerbation risk Serum IgE level ± atopy was not predictive of exacerbation risk †Pooled analysis of 2016 adult and adolescent patients randomized to receive placebo across 7 multicenter, randomized, double-blind, placebo-controlled trials with asthma...
Eosinophil unit conversion calculator Convert your patient’s lab results to an absolute blood eosinophil count in cells/µL. Get absolute EOS counts PATIENT TYPES WHO MAY BENEFIT FROM NUCALA In your practice, you may know these types of patients with severe eosinophilic asthma (SEA). ...
which is associated with more severe disease and nasal polyp recurrence and can bedetected by blood eosinophil count, a biomarker measured by a simple blood test.6-9IL-5 is a key cytokine driving this type 2 inflammation and is present at high levels in nasal polyp tissue.4-8Although surger...
(s) with or without OCS. Patients enrolled in this trial were required to have at least 1 of the following 4 pre-specified criteria in the previous 12 months: blood eosinophil count ≥300 cells/mcL, sputum eosinophil count ≥3%, exhaled nitric oxide concentration ≥50 ppb, or deterioration ...
Key secondary endpoints: healthcare resource utilisation (HCRU), oral corticosteroid (OCS) use, lung function and symptom control (Asthma Control Test [ACT] scores).#Overall, 525 patients with SA burden pre-initiation (geometric mean blood eosinophil count [BEC] 490.7 cells/l; 31.4% prior ...