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Larotrectinib was also active in patients with brain metastases, with an ORR of 71%26. A similar analysis of entrectinib inNTRKfusion-positive cancers showed an ORR of 63.5%, median duration of response of 12.9 months, median progression-free survival of 11.2 months, and intracranial ORR ...
View Patent Images: Download PDF 5362119 US Patent References: 5205332Wind-shield blind1993-04-27Lii296/97.8 5089912Retractable antiglare shield for exterior rear view mirrors1992-02-18Simin296/97.2 5085473Air actuated car curtain device1992-02-04Yang296/97.8 ...
View Patent Images: Download PDF 11339202 US Patent References: 20210238256 FUSION PROTEIN 2021-08-05 Westbrook 10751389 Therapeutic use of p75NTR neurotrophin binding protein 2020-08-25 Westbrook 10683339 P75NTR binding protein-Fc fusion protein and methods of treating pain 2020-06-16 Westbrook ...
patch-clamp mode with an internal recording solution containing (in mM): 122.5 K+gluconate, 8 KCl, 4 Mg2+ATP, 0.3 Na+GTP, 10 HEPES, 0.2 EGTA, 2 MgCl2with pH set to 7.2–7.3, and osmolarity to 270–280 mosmol/l. AP firing was recorded in current clamp at free membrane ...
Labs were free to select their antibody and detection system of preference but were asked to provide information on the antibody, protocol and scoring method. Upon TRK staining, one or two pathologists of each centre reviewed and interpreted the staining. The laboratories were requested to return ...
Resection margins are free of tumor. After wound healing was completed, the patient was started on adjuvant radiation therapy (a total of 5000 cgy) given this being a high grade tumor > 10 cm. Larotrectinib was held during adjuvant radiation due to a lack of data on concurrent ...