心肌细胞受到牵拉后,分泌初始基因产物前 BNP 前体 (pre-proBNP),该肽的一个 26 氨基信号肽被去除,形成含 108 个氨基酸的 BNP 前体 (proBNP),后者在内切酶的作用下裂解为含有 76 个氨基酸、无生物活性的 NT-roBNP 和含有 32 个氨基酸、有活...
We examined the predictors of CV mortality and morbidity in a high risk population with T2DM (history of chronic kidney or CV disease or both) in the Aliskiren Trial in Type 2 Diabetes Using Cardiorenal Endpoints (ALTITUDE). Methods In 8415 patients with complete data, we identified the ...
综述Zongshu 《中国医学创新》第 20 卷第 3 期(总第 609 期)2023 年 1 月 BNP及NT-proBNP在慢性肾脏病中的 研究进展 闫倩① 石东英① 【摘要】 慢性肾脏病(chronic kidney disease,CKD)由于其高发病率和死亡率,已成为全世界范 围内的严重健康问题,心血管疾病(cardiovascular disease,CVD)是 CKD 患者常见...
The value of a laboratory test increases with pre-test knowledge of the predictive val ue for a negative and positive test result. BNP and NT-proBNP have different pharmacokinetics and modes of clearance. We attempted to further clarify the effect of chronic kidney disease (CKD) on the BNP ...
Chronic kidney disease N-terminal brain natriuretic peptide precursor Cardiac function Full-Text Cite this paper Add to My Lib Abstract: 目的探讨慢性肾脏疾病(CKD)患者N末端脑利钠肽前体(NT-proBNP)水平及在评价CKD患者心功能中的价值。方法收集2013年1月至2014年12月以慢性肾脏相关疾病为主诊的住院...
〔摘 要〕 目的:探讨 N -端脑钠肽前体（N - terminal pre brain natriuretic peptiUe,NT -proBNP ）、高敏肌钙蛋—T （ high -sexsidvity troponin T ,hs -TnT ）对慢性肾脏病 4 期（chronic kidney disease stage 4，CKD4）患者急性失代偿心衰（acute Uecom- pensated heart...
1. National Kidney Foundation, “K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification”, Am. J. Kidney Dis. (2002), Feb; 39 (2 Suppl 1): pp. S1–266. 2. Go A S, Chertow G M, Fan D, McCulloch C E, Hsu C Y,“Chronic kidn...
Objective To evaluate the value of serum iPTH,plasma BNP and NT-pro BNP in the evaluation of cardiac function in patients stage 5 with chronic kidney disease( CKD).Methods Eighty stage 5 CKD patients with varying degrees of heart failure were selected to compare the serum iPTH,plasma BNP,NT...
强强联合守护“心”防线心衰现状概述心衰是各种心脏疾病的严重表现或晚期阶段,其患者死亡率和再住院率居高不下。据统计,2012-2015年我国35岁及以上心衰患者已达1,370万,且每年新发病例高达297万。随着人口老龄化与医疗水平的发展,我国心衰患病率呈持续升高趋势[1]。心衰诊断标志物🔷BNP & NT-proBNPBNP和NT-proBNP...
【Keywords】 heartfailure; kidneyfunction; NT‐proBNP 慢性心力衰竭(CHF)是一类严重的临床综合征 ,人群发 病率约2 ‰ ,近20 年来 ,其发病率还有所增加。 肾脏被看作是 循环系统的一个组成部分 ,心力衰竭可引起肾脏的一系列病理 生理改变 ,导致肾功能下降 ,反之 ,肾功能的恶化也可加重心力 衰竭,从而引起恶...