Despite a large decrease in locomotor activity, FL-PGC-1α-/- mice exhibited the surprising ability to attenuate HFDinduced obesity. Reduced fat mass in FL-PGC-1α-/- mice was closely associated with an increase in body temperature, energy expenditure, and whole-body fatty acid oxidation (...
At room temperature, NT-PGC-1α and NT-PGC-1α254 were produced from conventional exon 1a-derived transcripts in brown adipose tissue of wild type and FL-PGC-1α−/− mice, respectively. However, cold exposure shifted transcription to exon 1b, increasing exon 1b-derived mRNA levels. ...
Jun HJ, Gettys TW, Chang JS: Transcriptional activity of PGC-1α and NT-PGC-1α is differentially regulated by twist-1 in brown Fat metabolism. PPAR Res. 2012, 2012: 320454- CentralJun HJ, Gettys TW, Chang JS. Transcriptional Activity of PGC-1alpha and NT-PGC-1alpha Is Differen- ...
将肌管与nt-3(100ng/ml)孵育48小时,然后通过qpcr检测代谢标记物(pgc1a、hk1、pk1)的相对mrna表达(图3b),并通过elisa检测细胞培养基中的葡萄糖消耗与乳酸产生的关系(图3c)。(图3d)在nt-3(100ng/ml)治疗48小时后,成肌细胞与肌管中肌细胞生成素以及nt-3受体p75ntr和trkc的相对表达水平。gapdh在分析中作为管...
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而过氧化物酶增殖激活受体γ因子1(PPARGC1,也称为PGC-1)是线粒体生物合成和能量代谢转录共激活关键因子,通过与多种核受体包括雌激素受体(ESRR)、过氧化物酶增殖激活受体(PPAR)和核呼吸因子(NRF)等相互作用,在心脏中调控线粒体生物...
补充PQQ会开启由PGC-1a调控的基茵表达途径,PGC-1a是一种众所周知的线粒体生物发生激佸剂。这似乎是通过激佸SIRT1(一种沉默的调节蛋白)来实现的。蕞近的许多研究表明,Sirtuins 有助于调节细胞健康,预防疾患和与年龄相关的功能丧失,并在延长寿命方面发挥作用。
Gordonia rubripertincta strain CWB2 plasmid pGCWB2 Gryllotalpicola sp. 2DFW10M-5 plasmid unnamed1 Haematobacter massiliensis strain OT1 plasmid pOT1-6 Haematobacter massiliensis strain OT1 plasmid pOT1-7 Haematobacter massiliensis strain OT1 plasmid pOT1-8 Haematobacter massiliensis strain OT...
生殖细胞肿瘤的起源被推测为原始生殖细胞(PGC),这些细胞错误迁移至中枢神经系统,并作为异位胚胎细胞进行增殖。生殖细胞肿瘤的遗传学机制包括MAPK和PI3K通路的改变,以及以12p获得为代表的染色体异常。此类肿瘤的DNA甲基化水平整体较低,与PGCs一致...