CONCLUSIONS: NSABP-B27 is an effective neoadjuvant regimen. Despite including higher risk patients, pCR is similar to the original NSABP-B27 and many other anthracycline-taxane-based regimens. Tumor size, LN status, hormone receptors status, but not age, were significant factors in achieving pCR....
之后 NSABP连续的辅助治疗试验涉及蒽环、紫杉以及“密集”等多种方案,其中一些研究似乎平庸,然而其在DFS增量收益和挽救生命方面做出的巨大贡献是不容置疑的。1988年,NSABP B18和B27两项研究建立了术前新辅助治疗PCR和远期生存的相关性。2012年美国FDA用PCR暂时替代远期...
NeoadjuvantDocetaxelAnthracyclineMajority of Jordanian breast cancer patients present at a relatively young age and with locally advanced disease highlight the importance of neoadjuvant chemotherapy. This study evaluated the efficacy and safety of NSABP-B27 regimen in high-risk patients in daily clinical ...