Humanized mice expressing Human Leukocyte Antigen (HLA) class I or II transgenes have been generated, but the role of class Ivsclass II on human T and B cell reconstitution and function has not been investigated in detail. Herein we show that NRG (NOD.RagKO.IL2R纬cKO) mice expressing HLA...
2022年11月18日,解放军中部战区总医院向光大教授团队在Nature metabolism杂志上发表Brown Adipose Tissue-Derived Nrg4 Alleviates Endothelial Inflammation and Atherosclerosis In Male Mice论文,发现了BAT源性Nrg4对雄鼠内皮细胞的保护作用及...
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Expression of ErbB4 in the neurons of Alzheimer’s disease brain and APP/PS1 mice, a model of Alzheimer’s disease. Anat Cell Biol. 2011;44:116–27. Article Google Scholar Chang KA, Shin KY, Nam E, et al. Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer’s disease...
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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice of the amyloid-尾 precursor protein (APP) leading to the generation of amyloid-尾 peptides that is central to the pathogenesis of Alzheimer's disease. ... AV Savonenko,T Melnikova,FM Laird...
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice of the amyloid-尾 precursor protein (APP) leading to the generation of amyloid-尾 peptides that is central to the pathogenesis of Alzheimer's disease. ... AV Savonenko,T Melnikova,FM Laird...
Through pharmacologic modification with an ErbB antagonist and NRG1 isoforms, we discovered that NRG/ErbB signaling does not modulate the development of contractures in neonatal mice. Instead, ErbB inhibition impeded growth in nonヾenervated skeletal muscles, whereas increased ErbB activation exacerbated...
2022年11月18日,解放军中部战区总医院向光大教授团队在Nature metabolism杂志上发表Brown Adipose Tissue-Derived Nrg4 Alleviates Endothelial Inflammation and Atherosclerosis In Male Mice论文,发现了BAT源性Nrg4对雄鼠内皮细胞的保护作用及...
The H6c7-SLC3A2-NRG1 cells formed tumors when implanted in the subcutaneous flank of immune compromised mice (after about 10 weeks). Furthermore, a dependency of the transformed cell on this oncogene for growth and survival was also observed. Zenocutuzumab effectively inhibited proliferation of ...