antibody form【抗体形式】 purified immunoglobulin antibody product type primary antibodies clone【克隆】 polyclonal form【形式】 buffered aqueous solution mol wt【分子量】 antigen 26.1 kDa species reactivity human technique(s) western blot: 1 μg/mL NCBI accession no.【NCBI登记号】 NM_013958.1 UniProt...
Merus is a clinical stage oncology company developing innovative full-length human bispecific and trispecific antibody therapeutics, referred to as Multiclonics®. Multiclonics® are manufactured using industry standard processes and have been observed in preclinical and clinical studies to...
Full size image We made amino acid exchanges to alanines in the NRG1.1 predicted α1-helix E11/E27 (denoted EE) and L21/K22 (LK) pairs and a non-functional NRG1.1 G199K200T201/AAA P-loop variant (denoted GKT). When co-expressed with Arabidopsis EDS1 and SAG101 in the Nb epss TNL...
Human epidermal growth factor receptor 2 (HER2) and HER3 form a potent pro-oncogenic heterocomplex1,2,3 upon binding of growth factor neuregulin-1β (NRG1β). The mechanism by which HER2 and HER3 interact remains unknown in the absence of any structures of the complex. Here we isolated ...
Please see full Prescribing Information, including Boxed WARNING, atBIZENGRI.com/pi. About BIZENGRI® BIZENGRI®is a bispecific antibody that binds to the extracellular domains ofHER2andHER3expressed on the surface of cells, including tumor cells, inhibitingHER2:HER3dimerization and preventingNRG1...
However, unlike tup1 cells, nrg1 cells can form normal hyphae, generate chlamydospores at normal rates and grow at 42掳C. Transcript profiling of 2002 C.albicans genes reveals that CaNrg1 represses a subset of CaTup1-regulated genes, which includes known hypha-specific genes and other ...
Full size table CSF NRG1 and BACE1 results The results of CSF NRG1 and BACE1 levels are shown in Tables 1 and 2 and Fig. 2. For NRG1 ELISA tests, intra- and inter-assay variations were respectively 0.56% and 4.52%; 4.37% of results were under the detection limit, and the median di...
Merusis a clinical-stage oncology company developing innovative full-length human bispecific and trispecific antibody therapeutics, referred to asMulticlonics®. Multiclonics®are manufactured using industry standard processes and hav...
Full size image The real-time quantitative fluorescence PCR analysis revealed that both the NRG1 and the ErbB4 mRNAs were significantly decreased in the amygdala of high-anxiety mice compared with the low-anxiety mice (t(6)=3.794 and 4.61, P=0.032 and 0.019, respectively; Figures 1c and d...
Full size image Next, we detected the effect of Nedd4l knock-down on the NRG1 level and its ubiquitination. The results revealed that knock-down of Nedd4l in the mPFC blocked the decrease in NRG1 level and prevented the increase in NRG1 ubiquitination in CSDS mice (Fig. 5h–k). Mean...