fibrosismacrophagemyocardial infarctionsenescenceAppropriate fibrotic tissue formation after myocardial infarction (MI) is crucial to the maintenance of the heart's structure. M2‐like macrophages play a vital role in post‐MI fibrosis by activating cardiac fibroblasts. Because the mechanism ...
Alt text 5.Prrx1 restricts fibrosis prrx1b-/-细胞在簇2少但是在簇3多,分别对簇2和3进行GO分析,发现簇2和3虽然都表达活化成纤维细胞marker如postnb,但是簇3更富集参与 TGFβ 信号传导的基因(tgfb1a,tgfb2,tgfb3)、细胞外基质蛋白和胶原纤维组织,簇2缺少纤维化相关基因的表达。推测prrx1b-/-突变体损伤心...
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Dimethylnitrosamine ()-induced was used as an experimental model to study -gene expression during liver fibrogenesis. Increase in the concentrations of the for type I, III, and IV ...
Moreover, EMT also helps promote hepatic fibrosis by providing a pre-metastatic micro- environment [35]. A plethora of studies confirms the influential role of miRNAs in EMT process [36, 37]. In the current study, miR-296-5p showed a positive correl- ation with E-cadherin level, and ...
a NRG1 antibody fusion comprising an ERBB3 antagonistic antibody which selectively signals through ERBB4 preferentially over ERBB3, on atrial fibrosis and AF inducibility.Methods: Atrial samples were harvested from male rats (Wistar Han, 10 weeks old), cut into small pieces (1-2mm2) and kept ...
Nrg1/ErbB Signaling-Mediated Regulation of Fibrosis After Myocardial Infarctiondoi:10.1101/2021.01.29.428912Manabu ShiraishiAtsushi YamaguchiKen SuzukiCold Spring Harbor Laboratory
In our previous study, we observed ovarian fibrosis in both obese and aging mice with intracellular lipid droplets in the fibrotic ovaries. Although the importance of mitochondria in ovarian fibrosis has been recognized in pharmacological studies, their role in lipid metabolism remains...