Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells. Cancer Res. 2024 Jan 16;84(2):258-275. doi: 10.1158/0008-5472.CAN-23-1448. PMID: 37930937; PMCID: PMC10790129. [3]Chen Y, ...
cardiac fibroblastfibrosismacrophagemyocardial infarctionsenescenceAppropriate fibrotic tissue formation after myocardial infarction (MI) is crucial to the maintenance of the heart's structure. M2‐like macrophages play a vital role in post‐MI fibrosis by activating cardiac fibroblasts. Becaus...
9. These studies allowed clearly demonstrating that the heterogeneous fibroblast population of the blastema loses its adult features, adopts a multipotent skeletal progenitor phenotype, and expresses genes of
fibroblast growth factor 2; tgGCS-EGFP, germ cell specific-enhanced green fluorescence protein-encoding transgene; GDNF, glial cell line derived neurotrophic factor; GFRa1, GDNF family receptor alpha 1; HBE or HBEGF, heparin-binding-epidermal growth factor; IGEPAL, octylphenoxypolyethoxyethanol; KIT...
Cancer-associated fibroblastNeuregulin 1 (NRG1), a ligand for HER3 and HER4 receptors, is secreted by both pancreatic tumor cells (PC) and cancer-associated fibroblasts (CAFs), the latter representing the most abundant compound of pancreatic stroma. This desmoplastic stroma contributes to Pancreatic...
Further pt_lung_C028 with TP53R248L and SMARCA4E1056stop mutations also harboured a WASF2-FGR fusion where the kinase domain of fibroblast growth factor is retained. These three cases are representative examples of private fusions and the additional events that coexist in NSCLC tumours. As our...