当临床使用顺铂(DDP)长期治疗时,肿瘤细胞会激活核因子红细胞样2相关因子2(Nrf2)通路,促进其下游抗氧化基因如醌氧化还原酶1、血红素氧化酶1(HO-1)及药物转运体蛋白的表达产生耐药。肿瘤细胞耐药过程十分复杂,常涉及多个通路,包括Nrf2通路与自...
In conclusion, the current data suggest that glyceollins induced phase 2 detoxifying enzymes likely through promoting nuclear translocation of Nrf2, which is known to be regulated by phosphorylation of Nrf2 and/or disrupting Keap1-Nrf2 complex formation. 展开 关键词: Glyceollins Isoflavones Nrf2 ...