Using genome editing, we have generated mutants for nppa and nppb, and found that single mutants were indistinguishable from wild type, whereas nppa/nppb double mutants displayed heart morphogenesis defects and pericardial oedema. Analysis of atrioventricular canal (AVC) markers show expansion of bmp4...
2.NPPA基因RS5063高血压组与对照组无差异. 结论:NPPB基因RS198389多态性位点与海南岛人群原发性高血压的发病具有相关性,汉族和黎族间的比较,该基因与黎族高血压的相关性更为明显,而NPPA基因RS5063多态性位点与海南岛汉族和黎族人群原发性高血压发病没有明显相关性. 展开 关键词:...
内容提示:『IIIII JIIIII rll JII rl Jii rllll Jiii rlllll JiiifY32500077套贵朗,i|},巨学院须!i孕,fi4"伍绝Z学号:2013041研究生姓名:范美竹指导教师:云美玲专业:中西医结合临床(内)答辩时间:二。一六年五月万方数据 文档格式:PDF | 页数:50 | 浏览次数:198 | 上传日期:2017-11-01 12:32:53...
Structure and function of the Nppa–Nppb cluster locus during heart development and diseaseAtrial and brain natriuretic peptideEpigeneticsGene cluster... J Man,P Barnett,VM Christoffels - 《Cellular & Molecular Life Sciences Cmls》 被引量: 0发表: 2018年 with circulating natriuretic peptides and blo...
Christopher Newton-Cheh and colleagues report the identification of common variants at the NPPA-NPPB locus associated with plasma atrial natriuretic peptide concentration, as well as with lower systolic and diastolic blood pressure, and reduced risk of h
Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume 喜欢 0 阅读量: 88 作者:DR Grassini,AK Lagendijk,JE De Angelis,JD Silva,A Jeanes,N Zettler,NI Bower,BM Hogan,KA Smith ...
Christopher Newton-Cheh and colleagues report the identification of common variants at the NPPA-NPPB locus associated with plasma atrial natriuretic peptide concentration, as well as with lower systolic and diastolic blood pressure, and reduced risk of h
Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex ...
Regulatory Landscapes of Nppa and NppbEditorialschromatingene expressiongenomenatriuretic peptidesdoi:10.1161/CIRCRESAHA.120.318495Débora R. SobreiraMarcelo A. NóbregaCirculation Research
Hypertension Natriuretic peptide precursor A (NPPA); NPPB