Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex ...
Christopher Newton-Cheh and colleagues report the identification of common variants at the NPPA-NPPB locus associated with plasma atrial natriuretic peptide concentration, as well as with lower systolic and diastolic blood pressure, and reduced risk of h
Using genome editing, we have generated mutants for nppa and nppb, and found that single mutants were indistinguishable from wild type, whereas nppa/nppb double mutants displayed heart morphogenesis defects and pericardial oedema. Analysis of atrioventricular canal (AVC) markers show expansion of bmp4...
Hypertension Natriuretic peptide precursor A (NPPA); NPPB
Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heartepigenomicsgene expression regulationmyocardiumnatriuretic peptidesregulatory elementstranscriptionalRationaleMan, Joyce C. K.van Duijvenboden, KarelKrijger, Peter H. L.Hooijkaas, Ingeborg B.van der Made, Ingeborgde ...
Natriuretic peptide precursor A (NPPA; ANP); B-type natriuretic peptide (BNP; NPPB)A study in mice suggests ANP or BNP might increase energy expenditure to help treat obesity. Further details on the research, next steps and licensing status are discussed in the article.SciBX: Science-Business...
A: renin-angiotensin pathway; B: regulation by endothelin (EDN1); C: regulation by natruretic peptide (NPPA, NPPB, NPPC); D: the bradykinin-killikrien pathwayPeng, YueEugene, MelamudJohn, Moult
Natriuretic peptide precursor A (NPPA); NPPBGenomewide association studies identified common genetic variants at the NPPA-NPPB locus and suggested that activating the natriuretic peptide system could help treat hypertension.doi:10.1038/scibx.2009.315None...