After stable responding on the training dose, a full cocaine dose-response function (0.03–3.0 mg kgÀ1) was characterized according to a Latin square design. A second set of mice were implanted with cranial electrodes and trained in a discrete-trial current- threshold intracranial self-...
Although numerous clinical trials have shown that a single intravenous sub-anesthetic dose of ketamine (an NMDA receptor antagonist) can bring about full remission in hours, there has only been one dose-finding study (N = 4). We hypothe- sized that administration of ketamine in drug-free MDD...
pathological diagnosis, therapeutic treatments, cause of death, antemortem state, concomitant medical conditions, and lifestyle information such as cognitive performance, smoking, alcohol intake, medication history, and evidence of substance abuse (Torrey et al, 2000;Katsel et al, 2005b). Other necess...
of Functional Capacity Richard Keefe*, Stacy Ruse, Vicki Davis, Alexandra Atkins, Thomas Patterson, Meera Narasimhan, Philip Harvey Duke University Medical Center, Durham, North Carolina Background: Assessment of functional capacity is critical to the treatment of cognitive impairments in schizophrenia. ...
Cowan* UT Southwestern Medical Center, Dallas, USA Background: Repeated exposure to cocaine produces sensitized locomotion and reward-associated learning (conditioned place preference; CPP) in rodents. We previously reported that expression of active myocyte enhancer factor 2 (MEF2), a transcription ...
ALKS 5461 may 2.2 Intersection of Environment, Individual and Drug in Development of Substance Abuse in Adolescence Sari Izenwasser* represent a novel treatment of TRD with a rapid onset of effect. Disclosure: E. Ehrich, Part 1: Alkermes plc, Full time employee, Part 2: Alkermes plc, Full ...
Dysbindin-1, a protein that regulates aspects of early and late brain development, has been implicated in the pathobiology of schizophrenia. As the functional roles of the three major isoforms of dysbindin-1, (A, B, and C) remain unknown, we generated a
Methods: We investigated a reconsolidation paradigm in a sample of patients with clinically significant fear of flying (N = 89) receiving a full course of virtual reality exposure therapy in order to investigate if using a cue to reactive the memory of the feared stimulus 10 minutes before ...
Conclusions: The full description of tissue pathology in hippocampus during the first two weeks postnatal, peaks at hippocampus associated with the psychosis dimension in P15, and is recruited to the grin2b promoter just prior to the schizophrenia requires an animal preparation that is NMDAR switch....