ELN MRD工作组认为巩固治疗结束时是临床有意义的时间点,此期间MRD结果在NPM1突变AML中具有临床可操作性。qPCR结果显示,此时MRD持续性≥2%的患者应考虑进行alloHCT巩固,MRD低于该水平的患者为低水平分子MRD(low-level molecular MRD,MRD-LL...
单变量分析显示,WCC、FLT3-ITD、DNMT3A和WT1与MRD阳性的几率增加相关,而FLAG-Ida、GO和IDH2则与MRD阳性的几率降低相关(图3C)。在多变量分析中,NPM1非ABD型、FLT3-ITD、DNMT3A和WT1显著与MRD阳性的几率增加相关,而FLAG-Ida则与较低的MRD...
minimal residual disease (MRD)CAR-T cellsarsenic trioxideThe nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (NPM1mut-AML) has been reclassified as a distinct entity in the 2022 World Health Organi...
研究者通过实时定量PCR对患者的骨髓进行评估,监测MRD情况。 研究结果 01患者临床特征 该研究最终纳入了11例伴NPM1突变AML患者,年龄43-68岁。依据欧洲白血病网络2017(ELN 2017)危险分层,8例低危,3例中危(存在FLT3-ITD高等位基因比率);依据ELN2022危险分层,6例低危,5例中危(伴FLT3-ITD突变)。对于FLT3突变情况,在...
根据2017年ELN危险度分层为中危组AML患者共311例 [ 1 ],其中正常核型且NPM1 -CEBPA -FLT3-ITD - 230例,接受化疗诱导或造血干细胞移植获得形态学无白血病状态(MLFS)且进行早期MRD监测共162例,经1~2个疗程诱导化疗达MLFS且具有完整随访资料共124例。
Introduction: The European LeukemiaNet (ELN) 2022 guidelines recommend NPM1 real-time quantitative PCR (qPCR) for measurable residual disease (MRD) monitoring post-two cycles of intensive chemotherapy, end of treatment, and every 3 monthly thereafter on bone marrow, and every 4-6 weeks on periphe...
目的:探讨NPM1突变阳性急性髓系白血病(AML)患者化疗后早期微小残留病(MRD)水平与预后的关系.方法回顾性分析137例初治成人伴NPM1基因主要突变(A,B,D突变)AML患者的治疗结果,以及化疗后早期时间点MRD(NPM1突变转录本)水平对预后的影响.结果在137例患者中,男67例(48.9%),中位年龄49(16~67)岁,染色体正常核型107...
Importantly, this finding persisted in the European LeukemiaNet (ELN) 2017鈥揹efined favorable risk subset (14.7months vs not reached; P < .0001). Among patients who achieved NPM1 measurable residual disease (MRD) negativity, longer OS was observed in the entire cohort ( P = .015) as ...
monitoring of MRD with the ELN prognostication model can help to guide therapeutic decisions. Here, we provide examples of instructive cases ofNPM1-mutated AML, in order to provide criteria for the appropriate diagnosis and therapy of this frequent leukaemia entity....
过度表达现象,NPM1高表达者提示预后差,完全缓解率低,可作为AML预后不良的指标,PCR动态检测AML患者治疗前后NPM1表达水平,可作为判断AML预后和监测微小残留病(MRD)的... 李明,汤爱萍,余莉,... - 《重庆医学》 被引量: 2发表: 2012年 103例儿童急性髓系白血病的临床特征和预后因素分析 分析AML患儿初诊时的一般资...