另外一项来自MD安德森癌症中心的回顾性队列研究,共纳入了303例接受一线AML治疗的NPM1mut患者,维奈克拉+去甲基化药物(HMA)治疗的复合缓解率可高达96%,与强诱导化疗治疗相似,强诱导化疗为3.7年,而维奈克拉+HMA治疗组,中位OS仍未达到[5]。 此外,一...
AML with mutated NPM1 typically shows a good response to induction therapy. Cases with a normal karyotype, in the absence of FLT3―ITD mutation, have a characteristically favourable prognosis. Younger patients with a normalkaryotype and no FLT3―...
关键词 急性髓系白血病;微小残留病;NPM1 基因突变;化疗;预后中图分类号 R733.71 文献标识码 A doi:10.19746/j.cnki.issn1009-2137.2020.01.016Correlation of Early Minimal Residual Disease Level with Prognosis in AML Patients with NPM1 Mutation Positive after ChemotherapyWANG Li - Juan 1 , LI Tan...
虽然NPM1突变合并细胞遗传学异常较为少见,但不良细胞遗传学对NPM1mutAML患者的预后影响至关重要。例如,当前指南建议复发风险低的伴NPM1mut/FLT3-ITDneg/low突变的AML患者毋须接受造血干细胞移植(HSCT)治疗,但倘若不良细胞遗传学增加了复发风险,那治疗决策必然也会改变。本研究旨在评估世界9所研究或治疗中心2426例NPM...
根据NPM1mut/FLT3-ITDneg/lowAML患者的细胞遗传学数据,研究发现年龄和OS显著相关(P= 0.0096 ; 图3),例如年轻患者(<60岁)的不良细胞遗传学相关死亡风险为3.97,而老年患者(≥60岁)为1.95。EFS和CIR结果类似。伴不良细胞遗传学的年轻患者有2/3的可能性获得CR(OR, 0.29; 95% CI, 0.12～0.71;P=0.0062)但同时...
目的研究伴有NPM1基因突变的急性髓系白血病(AML)患者的免疫表型特征。方法采用流式细胞术检测237例初诊AML患者的免疫表型,并采用实时定量PCR方法对NPM1基因突变进行筛查,比较NPM1突变型和野生型患者的免疫表型差异。结果NPM1突变型患者占所有AML患者的19.0%(45/237),与野生型相比其CDmCDm、HLA—DR、CD15、CD19表达...
We also discuss clinical consequences of mutations, associated gene expression patterns and the role of NPM1 mutations in informing prognosis and therapeutic decisions and predicting relapse in AML.doi:10.1038/leu.2017.30E M HeathS M ChanM D Minden...
Mutant (mt) NPM1 may also be co-expressed with the internal tandem duplications in FLT3 (FLT3-ITD), which confers poor prognosis in AML. Additional genetic mutations that coexist with mt-NPM1 are described. This chapter also covers the domain structure, genetic alterations, as well as the ...
The common molecular genetic changes in non-M3 AML includes FLT3, NPM1, DNMT3A and IDH mutations. This paper mainly reviews the characteristics of the above four genes, pathogenesis and prognosis of non-M3 AML.马莹莹030001 太原白血病·淋巴瘤...
The clinical characteristics, bone marrow/peripheral blood cell morphology, immunophenotype, cytogenetics, molecular biology and overall survival of different groups were retrospectively analyzed, and the risk factors affecting the prognosis of AML were also explored. Cox multivariate regression was used to...