Find the latest research in npj Parkinson's Disease, an open access, peer reviewed journal with a 6.7 Impact Factor and 11 days to first decision.
The current nosological concept of α-synucleinopathies characterized by the presence of Lewy bodies (LBs) includes Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB), for which the term “Lewy body diseas
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4f). The expression of Parkinson disease protein 7 (PARK7), a stress sensor and redox-sensitive chaperone, was unchanged throughout the three phases of the mission in the muscle biopsies of astronaut B but it decreased over 90% at R + 0 for astronaut A (Fig. 4g). Interestingly, ...
, reminiscent to the observed alterations during pmvk-induced senescence in normal cell. we have previously reported that errα-null mice are protected from hfd-induced non-alcoholic fatty liver disease (nafld) 54 , which is characterized by liver steatosis. senescent cells accumulate in the liver...
Perspective Open access Published: 01 July 2023 Perspective on the current state of the LRRK2 field Jean-Marc Taymans, Matt Fell, Tim Greenamyre, Warren D. Hirst, Adamantios Mamais, Shalini Padmanabhan, Inga Peter, Hardy Rideout & Avner Thaler npj Parkinson's Disease volume...
ArticleOpen access07 October 2023 Introduction Parkinson’s disease (PD) is a neurodegenerative disorder, the prevalence of which is increasing worldwide, affecting an estimated 9.4 million individuals as of 20201,2. PD is associated with aggregations in the brain known as Lewy bodies, composed prim...
Parkinson’s disease (PD) is affecting about 1.2 million patients in Europe with a prevalence that is expected to have an exponential increment, in the next decades. This epidemiological evolution will be challenged by the low number of neurologists able to deliver expert care for PD. As PD ...
and one study of ankylosing spondylitis (AS) (ZhouC_2020) also showed over 20% decrease in species richness and diversity. Conversely, increases in species richness and diversity were found in patients with Parkinson’s disease (PD) (QianY_2020 and MaoL_2021) and atrial fibrillation (AF) (...
Dopaminergic neurons of the substantia nigra are selectively vulnerable to mitochondrial dysfunction, which is hypothesized to be an early and fundamental pathogenic mechanism in Parkinson’s disease (PD). Mitochondrial function depends on the successful import of nuclear-encoded proteins, many of which ...