Find the latest research in npj Parkinson's Disease, an open access, peer reviewed journal with a 6.7 Impact Factor and 11 days to first decision.
The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Q1 (green) comprises the quarter of the journals with the highest values, Q2 (yellow) the second highest values, Q3 (orange) the third highest values and Q4 (red) the lowest ...
In Parkinson’s disease brain, direct comparison of PLA and immunohistochemistry with the MJF-14 antibody shows widespread α-synuclein pathology preceding the formation of conventional Lewy pathology. In conclusion, we introduce an improved α-synuclein aggregate PLA to uncover abundant non-inclusion ...
Mitochondrial dysfunction has been suggested to contribute to Parkinson’s disease pathogenesis, though an understanding of the extent or exact mechanism of this contribution remains elusive. This has been complicated by challenging nature of pathway-bas
Postural instability is one of the most disabling motor signs of Parkinson’s disease (PD) and often underlies an increased likelihood of falling and loss of independence. Current clinical assessments of PD-related postural instability are based on a retropulsion test, which introduces human error ...
CommentOpen Access01 Nov 2023 The elephant in the room: critical reflections on mortality rates among individuals with Parkinson’s disease In our efforts to create more public awareness about Parkinson’s disease, we often emphasize the tremendous impact of this common disease on an individual’...
Parkinson’s disease (PD), the most common motor neurodegenerative disorder, lacks a reliable biomarker for early detection. Elevated dopa decarboxylase (DDC) levels show promise as a biomarker for PD, distinguishing it from other neurodegenerative disea
Subthalamic deep brain stimulation is an advanced therapy that typically improves quality of life for persons with Parkinson’s disease (PD). However, the effect on caregiver burden is unclear. We recruited 64 persons with PD and their caregivers from a
et al. MicroRNA-205 regulates the expression of Parkinson’s disease-related leucine-rich repeat kinase 2 protein. Hum. Mol. Genet. 22, 608–620 (2013). Article CAS PubMed Google Scholar Lu, S. Y. et al. miR-218-2 regulates cognitive functions in the hippocampus through complement ...
Almost 2 decades after linking LRRK2 to Parkinson’s disease, a vibrant research field has developed around the study of this gene and its protein product. Recent studies have begun to elucidate molecular structures of LRRK2 and its complexes, and our un