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Triple-negative breast cancer (TNBC) refers to a subgroup of breast cancer (BC) defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Accounting for 15–20% of all BCs, TNBC is more prevalent in younger women, Afr...
To date, four cohorts of rare/ultra-rare cancers (metaplastic breast cancer, angiosarcoma, and two cohorts of neuroendocrine tumors) have been published in the peer-review literature and show a subset of highly immunotherapy-responsive patients22,23,24,25. Approximately 10 additional cohorts of rare...
While several resources exist that interpret therapeutic significance of genomic alterations in cancer, many regional real-world issues limit access to drugs. There is a need for a pragmatic, evidence-based, context-adapted tool to guide clinical management based on molecular biomarkers. To this end...