Furthermore, there is a novel proposed mechanism, in which metformin modulates serum estrogen levels, as observed in the phase III trial ‘MA.32’ that has compared metformin versus placebo in patients with breast cancer and without diabetes [75]. Another promising strategy is the repurposing of...
type2diabetesBasal insulin peglispro (BIL) has a longer duration of action than conventional insulin analogues and a hepato‐preferential mechanism of action. This study assessed whether BIL was non‐inferior to isophane insulin (NPH) in reducing HbA1c in insulin‐naïve patientswith type 2 ...
Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation. This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism. Pretreatment of "semimature" 5-day human mon...
These compounds may become concentrated in organs of aquatic organisms, especially those at the top of the food chain. The main mechanism of action of these organophosphates and carbamate insecticides involves the inhibition of acetylcholinesterase (AChE). However, if exposure to the inhibitor is ...
OBJECTIVE -- Insulin detemir is a soluble basal insulin analog with a unique mechanism of protracted action designed to reduce the variability associated w... Vague,Philippe,Selam,... - 《Diabetes Care》 被引量: 328发表: 2003年 Insulin detemir compared with NPH insulin in children and adolescen...
(13.9 vs 17.7 events per patient year, respectively; p < 0.02) in a similar treat-to-target trial in type 2 diabetes, although here weight increased by a mean ≈3kg with both insulins.[21]Collectively, these studies imply that the mechanism behind the weight-sparing effect of insulin ...
(Romano et al., 1993; Lehman et al., 1996; Chen et al., 1998;Luschnig et al., 1998; Madlung et al., 1999).The mechanism by which auxin modulates plant growth isstill not understood; however, the gene activation hypothe-sis proposes that auxin regulates the transcription of spe-cif...
3aDivisionofBiologicalSciences,UniversityofMissouri,Columbia,Missouri65211bDivisionofBiologicalScience,GraduateSchoolofEnvironmentalEarthScience,HokkaidoUniversity,Sapporo060-0810,JapanOrganbendingthroughdifferentialgrowthrepresentsamajormechanismbywhichplantsareabletoadaptivelyaltertheirmorphologyinresponsetolocalchangesinthe...
One of the main regulatory proteins for dental health is osteocalcin, which is a crucial protein for bone metabolism and can be activated by vitamin K2. Dentin is the calcified tissue beneath the enamel on teeth, and osteocalcin can trigger the mechanism of stimulating the growth of new dentin...
Slider Movement Double Action Slider Drive Mechanism Cam Press Controlling Mode Artificial Automatic Grade Automatic Power Source Mechanical Drive Precision High Precision Certification CE, ISO 9001 Condition New Transport Package Wooden Package Specification CE, IS...